IgM ELISA for leptospirosis diagnosis: a systematic review and meta-analysis / ELISA IgM para diagnóstico de leptospirose: revisão sistemática e meta-análise
Ciênc. Saúde Colet. (Impr.)
; 22(12): 4001-4012, Dez. 2017. tab, graf
Article
in En
| LILACS
| ID: biblio-890236
Responsible library:
BR1.1
ABSTRACT
Abstract A systematic review with meta-analysis was performed to estimate the accuracy of IgM ELISA for Leptospirosis diagnosis. A search of Medline, Lilacs, Embase, Cochrane Central Register of Controlled Trials and Grey literature (Google Scholar and British Library) was conducted. The medical subject headings (MeSHs) and the words "leptospirosis", "human leptospirosis" and "IgM ELISA" were used. Fifty-two studies were analyzed, which included 10,775 samples. The pooled sensitivity of all the studies was 86% (CI 95%, 85%-87%) and specificity was 90% (CI 95%, 89%-91%). In studies of the acute phase, the sensitivity and specificity were 84% (CI 95%, 82%-85%) and 91% (CI 95%, 90%-91%), respectively. In conclusion, IgM ELISA is sensitive for use as an initial screen for leptospiral infections.
RESUMO
Resumo O objetivo desta revisão sistemática e meta-análise foi avaliar a acurácia do ELISA IgM para o diagnóstico precoce da leptospirose em humanos. A busca foi realizada nas seguintes bases de dados Medline, PubMed, LILACS, Embase e Cochrane Central Register of Controlled Trials e Grey literature (Google Scholar and British Library). As palavras-chaves usadas foram "leptospirosis", "human leptospirosis" e "IgM ELI-SA". Foram analisados 52 estudos, que incluíram 10.775 amostras. A sensibilidade e especificidade combinada de todos os estudos foram 86% (CI 95%, 85%-87%) e 90% (CI 95%, 89%-91%), respectivamente. Nos estudos de fase aguda, a sensibilidade e especificidade foram, respectivamente, 84% (CI 95%, 82%-85%) e 91% (CI 95%, 90%-91%). Conclui-se que o ELISA IgM é um teste sensível para rastreamento inicial da leptospirose.
Key words
Full text:
1
Index:
LILACS
Main subject:
Immunoglobulin M
/
Enzyme-Linked Immunosorbent Assay
/
Leptospirosis
Type of study:
Diagnostic_studies
/
Screening_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Ciênc. Saúde Colet. (Impr.)
Journal subject:
SAUDE PUBLICA
Year:
2017
Type:
Article