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Burkholderia cepacia, cystic fibrosis and outcomes following lung transplantation: experiences from a single center in Brazil
de Souza Carraro, Danila; Carraro, Rafael Medeiros; Campos, Silvia Vidal; Iuamoto, Leandro Ryuchi; Braga, Karina Andrighetti de Oliveira; Oliveira, Lea Campos de; Sabino, Ester Cerdeira; Rossi, Flavia; Pêgo-Fernandes, Paulo Manuel.
  • de Souza Carraro, Danila; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Carraro, Rafael Medeiros; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Campos, Silvia Vidal; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Iuamoto, Leandro Ryuchi; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Braga, Karina Andrighetti de Oliveira; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Oliveira, Lea Campos de; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Sabino, Ester Cerdeira; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Rossi, Flavia; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Pêgo-Fernandes, Paulo Manuel; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas HCFMUSP. Sao Paulo. BR
Clinics ; 73: e166, 2018. tab, graf
Article in English | LILACS | ID: biblio-890746
ABSTRACT

OBJECTIVES:

To evaluate the impact of Burkholderia cepacia complex colonization in cystic fibrosis patients undergoing lung transplantation.

METHODS:

We prospectively analyzed clinical data and respiratory tract samples (sputum and bronchoalveolar lavage) collected from suppurative lung disease patients between January 2008 and November 2013. We also subtyped different Burkholderia cepacia complex genotypes via DNA sequencing using primers against the recA gene in samples collected between January 2012 and November 2013.

RESULTS:

From 2008 to 2013, 34 lung transplants were performed on cystic fibrosis patients at our center. Burkholderia cepacia complex was detected in 13 of the 34 (38.2%) patients. Seven of the 13 (53%) strains were subjected to genotype analysis, from which three strains of B. metallica and four strains of B. cenocepacia were identified. The mortality rate was 1/13 (7.6%), and this death was not related to B. cepacia infection.

CONCLUSION:

The results of our study suggest that colonization by B. cepacia complex and even B. cenocepacia in patients with cystic fibrosis should not be considered an absolute contraindication to lung transplantation in Brazilian centers.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Lung Transplantation / Burkholderia cepacia / Burkholderia Infections / Cystic Fibrosis Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Clinics Journal subject: Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Lung Transplantation / Burkholderia cepacia / Burkholderia Infections / Cystic Fibrosis Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Clinics Journal subject: Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR