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Inhibitory effect of Dendrobium officinale polysaccharide on human gastric cancer cell xenografts in nude mice
ZHANG, Liying; WANG, Fabao; REN, Xiubao.
  • ZHANG, Liying; Tianjin Medical University Cancer Institute and Hospital. National Clinical Research Center for Cancer. Department of Biotherapy. Tianjin. CN
  • WANG, Fabao; Tianjin Medical University Cancer Institute and Hospital. National Clinical Research Center for Cancer. Department of Biotherapy. Tianjin. CN
  • REN, Xiubao; Tianjin Medical University Cancer Institute and Hospital. National Clinical Research Center for Cancer. Department of Biotherapy. Tianjin. CN
Food Sci. Technol (SBCTA, Impr.) ; 38(1): 78-83, Jan.-Mar. 2018. tab
Article in English | LILACS | ID: biblio-892251
ABSTRACT
Abstract This study investigated the inhibitory effect of Dendrobium officinale polysaccharide (DOPA) on human gastric cancer cell SGC-7901 xenografts in nude mice. The nude mice with SGC-7901 xenografts were randomly divided into model, 5-fluorouracil (5-Fu), low-dose DOPA, middle-dose DOPA and high-dose DOPA group. The later four groups were intragastrically administrated with 100, 200 and 400 mg·kg-1·day-1 DOPA, 400 mg·kg-1·day-1 5-Fu and normal saline, respectively. After treatment for 20 days, the tumor inhibition rate of in high-dose DOPA group was basically equivalent to 5-Fu group. Compared with 5-Fu, DOPA had no obvious toxic side effect on spleen or thymus indexes, routine blood indexes or liver and kidney functions of nude mice. Compared with model group, the serum tumor necrosis factor-α and interleukin-2 levels in middle- and high-dose DOPA group were significantly increased (P < 0.05), Bax protein expression was significantly increased (P < 0.05), and Bcl-2 protein expression was significantly decreased (P < 0.05). DOPA can inhibit the growth of SGC-7901 cell xenografts in nude mice. The mechanism may be related to its increase of serum TNF-α and IL-2 levels, up-regulation of Bax protein expression and down-regulation of Bcl-2 protein expression.
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Full text: Available Index: LILACS (Americas) Main subject: Stomach Neoplasms / Xenograft Model Antitumor Assays Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Food Sci. Technol (SBCTA, Impr.) Journal subject: ALIMENTOS / Nutritional Sciences Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Tianjin Medical University Cancer Institute and Hospital/CN

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Full text: Available Index: LILACS (Americas) Main subject: Stomach Neoplasms / Xenograft Model Antitumor Assays Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Food Sci. Technol (SBCTA, Impr.) Journal subject: ALIMENTOS / Nutritional Sciences Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Tianjin Medical University Cancer Institute and Hospital/CN