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Which is best method for instillation of topical therapy to the upper urinary tract? An in vivo porcine study to evaluate three delivery methods
Liu, Zhenbang; Ng, Junxiang; Yuwono, Arianto; Lu, Yadong; Tan, Yung Khan.
  • Liu, Zhenbang; Tan Tock Seng Hospital. Department of Urology. SG
  • Ng, Junxiang; Tan Tock Seng Hospital. Department of Urology. SG
  • Yuwono, Arianto; Tan Tock Seng Hospital. Department of Urology. SG
  • Lu, Yadong; Tan Tock Seng Hospital. Department of Urology. SG
  • Tan, Yung Khan; Tan Tock Seng Hospital. Department of Urology. SG
Int. braz. j. urol ; 43(6): 1084-1091, Nov.-Dec. 2017. tab, graf
Article in English | LILACS | ID: biblio-892917
Responsible library: BR1.1
ABSTRACT
ABSTRACT

Purpose:

To compare the staining intensity of the upper urinary tract (UUT) urothelium among three UUT delivery methods in an in vivo porcine model. Materials and

methods:

A fluorescent dye solution (indigo carmine) was delivered to the UUT via three different

methods:

antegrade perfusion, vesico-ureteral reflux via in-dwelling ureteric stent and retrograde perfusion via a 5F open-ended ureteral catheter. Twelve renal units were tested with 4 in each method. After a 2-hour delivery time, the renal-ureter units were harvested en bloc. Time from harvesting to analysis was also standardised to be 2 hours in each arm. Three urothelium samples of the same weight and size were taken from each of the 6 pre-defined points (upper pole, mid pole, lower pole, renal pelvis, mid ureter and distal ureter) and the amount of fluorescence was measured with a spectrometer.

Results:

The mean fluorescence detected at all 6 predefined points of the UUT urothelium was the highest for the retrograde method. This was statistically significant with p-value less than <0.05 at all 6 points.

Conclusions:

Retrograde infusion of UUT by an open ended ureteral catheter resulted in highest mean fluorescence detected at all 6 pre-defined points of the UUT urothelium compared to antegrade infusion and vesico-ureteral reflux via indwelling ureteric stents indicating retrograde method ideal for topical therapy throughout the UUT urothelium. More clinical studies are needed to demonstrate if retrograde method could lead to better clinical outcomes compared to the other two methods.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Administration, Intravesical / Urothelium / Coloring Agents / Indigo Carmine Limits: Animals Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2017 Type: Article Affiliation country: Singapore Institution/Affiliation country: Tan Tock Seng Hospital/SG

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Full text: Available Index: LILACS (Americas) Main subject: Administration, Intravesical / Urothelium / Coloring Agents / Indigo Carmine Limits: Animals Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2017 Type: Article Affiliation country: Singapore Institution/Affiliation country: Tan Tock Seng Hospital/SG