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Super-selective robot-assisted partial nephrectomy using near-infrared flurorescence versus early-unclamping of the renal artery: results of a prospective matched-pair analysis
Lanchon, Cecilia; Arnoux, Valentin; Fiard, Gaëlle; Descotes, Jean-Luc; Rambeaud, Jean-Jacques; Lefrancq, Jean-Benjamin; Poncet, Delphine; Terrier, Nicolas; Overs, Camille; Franquet, Quentin; Long, Jean-Alexandre.
  • Lanchon, Cecilia; Grenoble University Hospital. Department of Urology. Grenoble. FR
  • Arnoux, Valentin; Grenoble University Hospital. Department of Urology. Grenoble. FR
  • Fiard, Gaëlle; Grenoble University Hospital. Department of Urology. Grenoble. FR
  • Descotes, Jean-Luc; Grenoble University Hospital. Department of Urology. Grenoble. FR
  • Rambeaud, Jean-Jacques; Grenoble University Hospital. Department of Urology. Grenoble. FR
  • Lefrancq, Jean-Benjamin; Grenoble University Hospital. Department of Urology. Grenoble. FR
  • Poncet, Delphine; Grenoble University Hospital. Department of Urology. Grenoble. FR
  • Terrier, Nicolas; Grenoble University Hospital. Department of Urology. Grenoble. FR
  • Overs, Camille; Grenoble University Hospital. Department of Urology. Grenoble. FR
  • Franquet, Quentin; Grenoble University Hospital. Department of Urology. Grenoble. FR
  • Long, Jean-Alexandre; Grenoble University Hospital. Department of Urology. Grenoble. FR
Int. braz. j. urol ; 44(1): 53-62, Jan.-Feb. 2018. tab
Article in English | LILACS | ID: biblio-892939
ABSTRACT
ABSTRACT Introduction Super-selective clamping of tumor-specific segmental arteries was developed to eliminate ischemia of the remnant kidney while limiting hemorrhage during partial nephrectomy. The objective is to evaluate the benefice of super-selective clamping on renal functional outcome, compared to early-unclamping of the renal artery. Materials and Methods From March 2015 to July 2016, data from 30 patients undergoing super-selective robot-assisted PN (RAPN) for a solitary tumor by a single surgeon were prospectively collected. Tumor devascularization was assessed using indocyanine green near-infrared fluorescence. A matched-pair analysis with a retrospective cohort undergoing early-unclamping was conducted, adjusting on tumor complexity and preoperative eGFR. Perioperative, oncologic and functional outcomes using DMSA-renal scintigraphy were assessed. Multivariate analysis was performed to identify predictors of postoperative renal function and de novo chronic kidney disease (CKD). Results Super-selective RAPN was successful in 23/30 patients (76.7%), 5 requiring secondary main artery clamping due to persistent tumor fluorescence. Matched-pair analysis showed similar operating time, blood loss, positives margins and complication rates. Super-selective clamping was associated with an improved eGFR variation at discharge (p=0.002), 1-month (p=0.01) and 6-month post-op (-2%vs-16% p=0.001). It also led to a better relative function on scintigraphy (46%vs40% p=0.04) and homolateral eGFR (p=0.04), and fewer upstaging to CKD stage ≥3 (p=0.03). On multivariate analysis, super-selective clamping was a predictor of postoperative renal function. Conclusion Super-selective RAPN leads to an improved preservation of renal function and a reduced risk of de novo CKD stage≥3, while keeping the benefit of main artery clamping on perioperative outcomes.
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Full text: Available Index: LILACS (Americas) Main subject: Renal Artery / Robotic Surgical Procedures / Ischemia / Kidney Neoplasms / Nephrectomy Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2018 Type: Article Affiliation country: France Institution/Affiliation country: Grenoble University Hospital/FR

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Full text: Available Index: LILACS (Americas) Main subject: Renal Artery / Robotic Surgical Procedures / Ischemia / Kidney Neoplasms / Nephrectomy Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2018 Type: Article Affiliation country: France Institution/Affiliation country: Grenoble University Hospital/FR