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Effects of Copaiba oil in the healing process of urinary bladder in rats
Feitosa Junior, Denilson José Silva; Carvalho, Luan Teles Ferreira de; Rocha, Ingrid Rodrigues de Oliveira; Brito, Camila Noura de; Moreira, Rodrigo Alencar; Barros, Charles Alberto Villacorta de.
  • Feitosa Junior, Denilson José Silva; Universidade Estadual do Pará. Laboratório de Cirurgia Experimental. Belém. BR
  • Carvalho, Luan Teles Ferreira de; Universidade Estadual do Pará. Laboratório de Cirurgia Experimental. Belém. BR
  • Rocha, Ingrid Rodrigues de Oliveira; Universidade Estadual do Pará. Laboratório de Cirurgia Experimental. Belém. BR
  • Brito, Camila Noura de; Universidade Estadual do Pará. Laboratório de Cirurgia Experimental. Belém. BR
  • Moreira, Rodrigo Alencar; Universidade Estadual do Pará. Laboratório de Cirurgia Experimental. Belém. BR
  • Barros, Charles Alberto Villacorta de; Universidade Estadual do Pará. Laboratório de Cirurgia Experimental. Belém. BR
Int. braz. j. urol ; 44(2): 384-389, Mar.-Apr. 2018. tab, graf
Article in English | LILACS | ID: biblio-892983
ABSTRACT
ABSTRACT Introduction The appropriate closure of the urinary bladder is important to many urologic procedures to avoid the formation of fistulas and strictures by excessive fibrosis. This paper presents the alterations in the bladder healing process of rats after the topical use of Copaiba oil (Copaifera reticulata). Material and Methods Ten male Wistar rats were used and randomly divided into two groups Control group (CG) injected 1ml/kg of saline solution on the suture line; and Copaiba group (CpG) 0.63ml/kg of copaiba oil applied to the suture line. Euthanasia was performed on the seventh day after surgery. The criteria observed were adherences formation, histopathological modifications and stereology for collagen. Results Both groups showed adhesions to the bladder, with no statistically significant difference (p=0.1481). The microscopic evaluation revealed a trend to more severe acute inflammation process on the CpG, but there was statistical difference only in the giant cells reaction (p=0.0472) and vascular proliferation (p=0.0472). The stereology showed no difference. Conclusion The copaiba oil modified the healing process, improving the quantity of giant cells and vascular proliferation, but not interfered in the collagen physiology.
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Full text: Available Index: LILACS (Americas) Main subject: Wound Healing / Urinary Bladder / Plant Oils / Fabaceae Type of study: Prognostic study Limits: Animals Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual do Pará/BR

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Full text: Available Index: LILACS (Americas) Main subject: Wound Healing / Urinary Bladder / Plant Oils / Fabaceae Type of study: Prognostic study Limits: Animals Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual do Pará/BR