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Antioxidant and hypoglycemic effects of Momordica cochinchinensis Spreng: (Gac) aril extract on reproductive damages in streptozotocin (STZ)-induced hyperglycemia mice / Efectos antioxidantes e hipoglucémicos del extracto de aril de Momordica cochinchinensis Spreng: (Gac) sobre los daños reproductivos en ratones con hiperglucemia inducida por streptozotocin (STZ)
Sampannang, Apichakan; Arun, Supatcharee; Sukhorum, Wannisa; Burawat, Jaturon; Nualkaew, Somsak; Maneenin, Chanwit; Sripanidkulchai, Bungorn; Iamsaard, Sitthichai.
  • Sampannang, Apichakan; Khon Kaen University. Faculty of Medicine. Department of Anatomy. Khon Kaen. TH
  • Arun, Supatcharee; Khon Kaen University. Faculty of Medicine. Department of Anatomy. Khon Kaen. TH
  • Sukhorum, Wannisa; Khon Kaen University. Faculty of Medicine. Department of Anatomy. Khon Kaen. TH
  • Burawat, Jaturon; Khon Kaen University. Faculty of Medicine. Department of Anatomy. Khon Kaen. TH
  • Nualkaew, Somsak; Mahasarakham University. Faculty of Pharmacy. Department of Pharmaceutical Sciences. Mahasarakham. TH
  • Maneenin, Chanwit; Ubonratchathani University. College of Medicine and Public Health. Department of Anatomy. TH
  • Sripanidkulchai, Bungorn; Center for Research and Development of Herbal Health Product. Faculty of Pharmaceutical Sciences. Khon Kaen. TH
  • Iamsaard, Sitthichai; Khon Kaen University. Faculty of Medicine. Department of Anatomy. Khon Kaen. TH
Int. j. morphol ; 35(2): 667-675, June 2017. ilus
Article in English | LILACS | ID: biblio-893038
ABSTRACT
The aim of present study was to investigate the effect of Momordica cochinchinensis (Gag) aril (GA) aqueous extract on male reproductive system of streptozotocin (STZ)-induced hyperglycemia (HG) mice. GA were extracted with distilled water (DW) and analyzed for in vitro antioxidant capacities. ICR male mice were divided into 7 groups 1) control, 2) DW, 3) GA 1000 mg/kg BW, 4) HG, 5) HG + glibenclamide, 6 and 7) HG + GA 500 and 1000 mg/kg BW respectively (7 mice/ group). In HG groups, mice were induced by STZ at single dose (150 mg/kg BW). They were treated for consecutive 35 days. All groups were compared for blood glucose levels, weights and histopathologies of reproductive organs, sperm concentration including testicular tyrosine phosphorylation protein patterns by Immuno-Western blotting. The results showed that GA processed antioxidant activities and could significantly decrease blood glucose levels and increase sperm concentration in HG mice. Moreover, GA could change the density of a testicular 70 kDa protein in HG-GA groups. In conclusion, GA extract could improve hyperglycemia and male reproductive damages in STZ-induced HG mice.
RESUMEN
El objetivo de este estudio fue investigar el efecto del extracto acuoso de Momordica cochinchinensis (Gag) aril (GA) en el sistema reproductor masculino de ratones hiperglucémicos inducidos por estreptozotocina (STZ). GA fue extraída con agua destilada (DW) y se analizaron las capacidades antioxidantes in vitro. Ratones ICR machos fueron divididos en 7 grupos 1) control, 2) DW, 3) GA 1000 mg / kg PC, 4) HG, 5) HG + glibenclamida, 6 y 7) HG + GA 500 y 1000 mg / kg PC, respectivamente (7 ratones / grupo). En los grupos HG, los ratones fueron inducidos con STZ en dosis única (150 mg / kg BW). Fueron tratados durante 35 días consecutivos. En todos los grupos se compararon los niveles de glucosa en sangre, los pesos y las histopatologías de los órganos reproductores, la concentración de espermatozoides, incluídos los patrones testiculares de proteínas tirosina fosforilada por Inmuno-Western blot. Los resultados mostraron que GA procesaba actividades antioxidantes y podían disminuir significativamente los niveles de glucosa en sangre y aumentar la concentración de espermatozoides en ratones HG. Además, GA podría cambiar la densidad de una proteína testicular de 70 kDa en grupos HG-GA. En conclusión, el extracto de GA podría mejorar la hiperglucemia y los daños reproductivos masculinos inducidos por STZ en ratones HG.
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Full text: Available Index: LILACS (Americas) Main subject: Testicular Diseases / Plant Extracts / Momordica / Hyperglycemia / Hypoglycemic Agents / Antioxidants Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2017 Type: Article / Project document Affiliation country: Thailand Institution/Affiliation country: Center for Research and Development of Herbal Health Product/TH / Khon Kaen University/TH / Mahasarakham University/TH / Ubonratchathani University/TH

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Full text: Available Index: LILACS (Americas) Main subject: Testicular Diseases / Plant Extracts / Momordica / Hyperglycemia / Hypoglycemic Agents / Antioxidants Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2017 Type: Article / Project document Affiliation country: Thailand Institution/Affiliation country: Center for Research and Development of Herbal Health Product/TH / Khon Kaen University/TH / Mahasarakham University/TH / Ubonratchathani University/TH