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Effects on alveolar bone of diabetes mellitus induced by streptozotocin in rats: histopathologic and immunohistochemical study / Efectos de la diabetes mellitus inducida por streptozotocina en el hueso alveolar de ratas: estudio histopatológico e inmunohistoquímico
Yilmaz, Nezih; Uysal, Ibrahim; Eratilla, Veysel; Sevgi, Irtegün; Günes Uysal, Rojdan Ferman; Eratilla, Elif; Hüseyin, Elbey; Ersin, Uysal; Deveci, Busra; Deveci, Engin.
  • Yilmaz, Nezih; Diyarbakir Oral and Dental Health Center. Department of Endodontics. TR
  • Uysal, Ibrahim; Diyarbakir Oral and Dental Health Center. Department of Prostodontics. TR
  • Eratilla, Veysel; University of Dicle. Facultad de Medicine. Department of Medical Biology. Diyarbakir. TR
  • Sevgi, Irtegün; Dicle University. Dental Faculty. Department of Oral Surgery. TR
  • Günes Uysal, Rojdan Ferman; Diyarbakir Oral and Dental Health Center. Department of Endodontics. TR
  • Eratilla, Elif; Dicle University. Department of Endodontics. Dental Faculty. Department of Operative Dentistry. TR
  • Hüseyin, Elbey; University of Dicle. Faculty of Medicine. Department of Plastic surgery. Diyarbakir. TR
  • Ersin, Uysal; Dicle University. TR
  • Deveci, Busra; Diyarbakir Oral and Dental Health Center. TR
  • Deveci, Engin; Dicle University. Medicine Faculty. Department of Histology. TR
Int. j. morphol ; 36(1): 206-211, Mar. 2018. tab, graf
Article in English | LILACS | ID: biblio-893212
Responsible library: CL1.1
ABSTRACT

SUMMARY:

The purpose of this study was to investigate effects of diabetes mellitus (DM) on the alveolar bone with histopathological and immunohistochemical methods. Wistar rats were divided into two groups, control and diabetes group. Control group was fed standard rat chow and drinking water for 8 weeks. Single dose (Streptozotocin) STZ (55 mg/kg), was dissolved in sodium citrate buffer and introduced intraperitoneal injection. Diabetes group and control group were compared in terms of glucose values. The blood glucose concentration in diabetic rats was significantly high (p <0.05). In diabetes group; periodontal membrane and the dilation of blood vessels, hemorrhage has also been a significant increase in inflammatory cells. In the diabetes group, osteonectin showed positive expression in periodontal membrane and showed negative expression in osteocytes of alveolar bone. Osteopontin expression in fibroblast cells and periodontal membrane collagen fibrils was positive, alveolar cells, osteocytes and bone matrix bone was found positive. Diabetes results showed that there formed periodontitis; due to the increase in inflammation inhibiting bone formation delaying the development of early bone cells.
RESUMEN
RESUMEN El objetivo de este estudio fue investigar los efectos de la diabetes mellitus (DM) sobre el hueso alveolar con métodos histopatológicos e inmunohistoquímicos. Las ratas Wistar se dividieron en dos grupos, grupo control y grupo de diabetes. El grupo control fue alimentado con comida estándar y agua potable durante 8 semanas. La dosis única Streptozotocina (STZ) (55 mg/ kg), se disolvió en tampón de citrato de sodio y se introdujo mediante inyección intraperitoneal. El grupo diabetes y el grupo control se compararon en términos de valores de glucosa. La concentración de glucosa en sangre en ratas diabéticas fue significativamente alta (p <0,05). En el grupo diabetes hubo un aumento significativo de la membrana periodontal y dilatación de los vasos sanguíneos y hemorragia, con un aumento significativo de células inflamatorias. En el grupo diabetes, la osteonectina mostró una expresión positiva en la membrana periodontal además se observó expresión negativa en los osteocitos del hueso alveolar. La expresión de osteopontina en fibroblastos y fibrillas de colágeno en membrana periodontal fue positiva, las células alveolares, osteocitos y hueso de la matriz ósea dio positivo. Los resultados de la diabetes mostraron que existía periodontitis, debido al aumento de la inflamación que inhibió la formación ósea retardando el desarrollo de células óseas tempranas.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Diabetes Mellitus, Experimental / Alveolar Process Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2018 Type: Article Affiliation country: Turkey Institution/Affiliation country: Dicle University/TR / Diyarbakir Oral and Dental Health Center/TR / University of Dicle/TR

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Full text: Available Index: LILACS (Americas) Main subject: Diabetes Mellitus, Experimental / Alveolar Process Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2018 Type: Article Affiliation country: Turkey Institution/Affiliation country: Dicle University/TR / Diyarbakir Oral and Dental Health Center/TR / University of Dicle/TR