Alveolar bone repair with strontium- containing nanostructured carbonated hydroxyapatite
J. appl. oral sci
;
26: e20170084, 2018. graf
Article
in English
| LILACS, BBO
| ID: biblio-893718
ABSTRACT
ABSTRACT Objective:
This study aimed to evaluate bone repair in rat dental sockets after implanting nanostructured carbonated hydroxyapatite/sodium alginate (CHA) and nanostructured carbonated hydroxyapatite/sodium alginate containing 5% strontium microspheres (SrCHA) as bone substitute materials.Methods:
Twenty male Wistar rats were randomly divided into two experimental groups CHA and SrCHA (n=5/period/group). After one and 6 weeks of extraction of the right maxillary central incisor and biomaterial implantation, 5 μm bone blocks were obtained for histomorphometric evaluation. The parameters evaluated were remaining biomaterial, loose connective tissue and newly formed bone in a standard area. Statistical analysis was performed by Mann-Withney and and Wilcoxon tests at 95% level of significance.Results:
The histomorphometric results showed that the microspheres showed similar fragmentation and bio-absorbation (p>0.05). We observed the formation of new bones in both groups during the same experimental periods; however, the new bone formation differed significantly between the weeks 1 and 6 (p=0.0039) in both groups.Conclusion:
The CHA and SrCHA biomaterials were biocompatible, osteoconductive and bioabsorbable, indicating their great potential for clinical use as bone substitutes.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Strontium
/
Bone Regeneration
/
Carbonates
/
Durapatite
/
Bone Substitutes
/
Tooth Socket
/
Nanostructures
/
Alginates
Limits:
Animals
Language:
English
Journal:
J. appl. oral sci
Journal subject:
Dentistry
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal Fluminense/BR
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