Chlorhexidine for prevention of alveolar osteitis: a randomised clinical trial
J. appl. oral sci
;
26: e20170245, 2018. tab, graf
Article
in English
| LILACS, BBO
| ID: biblio-893734
ABSTRACT
Abstract Objective To determine the effectiveness of chlorhexidine 0.12% mouthwash (CHX) after tooth extraction for the prevention of alveolar osteitis (AO). Material and methods We conducted a double-blind randomised clinical trial stratified by risk factors. We enrolled a cohort of 822 patients who underwent dental extractions, and were considered to be at risk of developing AO (previous surgical site infection, traumatic extraction, and tobacco smoking). After extraction, patients were randomly allocated for CHX group or placebo group, matched by risk factors. The primary outcome was clinical diagnosis of AO increasing postoperative pain for 4 d within and around the socket, and total or partial breakdown of the blood clot in the socket with or without bone exposure. Results Follow-up was completed by 744 participants (372 chlorhexidine and 372 placebo). We detected no significant differences between the two groups at baseline. After completed follow-up, risk factors were equally distributed between the two groups. Overall incidence of OA was 4.97%, in which 27 participants treated with placebo (7.26%) and 10 participants treated with CHX (2.69%) developed AO. CHX reduced the incidence of AO by 63% [Absolute Risk Reduction 4.57 (95% CI 1.5-7.7), Number Needed to Treat 21.88 (95% CI 13.0-69.3), Fisher's exact test p=0.006]. No adverse effects were reported. Conclusion The use of chlorhexidine 0.12% mouthwash after tooth extraction is safe and effective in reducing the incidence of AO in high-risk patients.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Postoperative Complications
/
Tooth Extraction
/
Chlorhexidine
/
Dry Socket
/
Mouthwashes
Type of study:
Controlled clinical trial
/
Etiology study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
J. appl. oral sci
Journal subject:
Dentistry
Year:
2018
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad Austral de Chile/CL
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