Can the six-minute walk distance predict the occurrence of acute exacerbations of COPD in patients in Brazil? / A distância percorrida no teste de caminhada de seis minutos pode predizer a ocorrência de exacerbações agudas da DPOC em pacientes brasileiros?
J. bras. pneumol
;
43(4): 280-284, July-Aug. 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-893848
ABSTRACT
ABSTRACT Objective:
To evaluate whether a six-minute walk distance (6MWD) of < 80% of the predicted value can predict the occurrence of acute exacerbations of COPD in patients in Brazil over a 2-year period.Methods:
This was a retrospective cross-sectional study involving 50 COPD patients in Brazil. At enrollment, anthropometric data were collected and patients were assessed for pulmonary function (by spirometry) and functional exercise capacity (by the 6MWD). The patients were subsequently divided into two groups 6MWD ≤ 80% of predicted and 6MWD > 80% of predicted. The occurrence of acute exacerbations of COPD over 2 years was identified by analyzing medical records and contacting patients by telephone.Results:
In the sample as a whole, there was moderate-to-severe airflow obstruction (mean FEV1 = 41 ± 12% of predicted) and the mean 6MWD was 469 ± 60 m (86 ± 10% of predicted). Over the 2-year follow-up period, 25 patients (50%) experienced acute exacerbations of COPD. The Kaplan-Meier method showed that the patients in whom the 6MWD was ≤ 80% of predicted were more likely to have exacerbations than were those in whom the 6MWD was > 80% of predicted (p = 0.01), whereas the Cox regression model showed that the former were 2.6 times as likely to have an exacerbation over a 2-year period as were the latter (p = 0.02).Conclusions:
In Brazil, the 6MWD can predict acute exacerbations of COPD over a 2-year period. The risk of experiencing an acute exacerbation of COPD within 2 years is more than twice as high in patients in whom the 6MWD is ≤ 80% of predicted.RESUMO
RESUMO Objetivo:
Avaliar se a distância percorrida no teste de caminhada de seis minutos (DTC6) < 80% do valor previsto pode predizer a ocorrência de exacerbações agudas da DPOC ao longo de 2 anos em pacientes brasileiros.Métodos:
Estudo transversal, retrospectivo, com 50 pacientes brasileiros com diagnóstico de DPOC. Após a admissão, os pacientes foram submetidos à coleta de dados antropométricos, avaliação da função pulmonar (resultados espirométricos) e da capacidade funcional de exercício (DTC6), sendo posteriormente divididos em dois grupos DTC6 ≤ 80% do predito e DTC6 > 80% do predito. A ocorrência de exacerbações agudas da DPOC ao longo de 2 anos foi identificada por meio de registros de prontuários e contato telefônico.Resultados:
A amostra geral apresentou obstrução moderada/grave ao fluxo aéreo (média de VEF1 = 41 ± 12% do predito) e média de DTC6 de 469 ± 60 m (86 ± 10% do predito). Nos 2 anos de seguimento após a realização do teste, 25 pacientes (50%) apresentaram exacerbação aguda da DPOC. O método de Kaplan-Meier mostrou que os pacientes com DTC6 ≤ 80% do predito apresentaram exacerbação mais frequentemente que pacientes com desempenho > 80% do predito (p = 0,01), enquanto o modelo de regressão de Cox mostrou que os pacientes no primeiro grupo apresentavam 2,6 mais chances de apresentar exacerbação em 2 anos em comparação ao segundo grupo (p = 0,02).Conclusões:
A DTC6 é capaz de predizer exacerbações agudas da DPOC em pacientes brasileiros ao longo de 2 anos. Pacientes com DTC6 ≤ 80% do valor predito têm mais que o dobro de chances de apresentar exacerbação em 2 anos.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Disease Progression
/
Pulmonary Disease, Chronic Obstructive
/
Walk Test
Type of study:
Diagnostic study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
J. bras. pneumol
Journal subject:
Pulmonary Disease (Specialty)
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual de Londrina/BR
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