Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazil
Mem. Inst. Oswaldo Cruz
;
112(10): 728-731, Oct. 2017. tab
Article
in English
| LILACS
| ID: biblio-894837
ABSTRACT
The classification of human papillomavirus (HPV) intratypic lineages by complete genome sequencing is a determinant in understanding biological differences in association with this disease. In this work, we have characterised complete HPV genomes from southern Brazil. Fifteen cervicovaginal Pap smear negative samples previously categorised as HPV-positive were sequenced using ultradeep sequencing, and 18 complete genomes from 13 different HPV types were assembled. Phylogenetic and genetic distance analyses were performed to classify the HPV genomes into lineages and sublineages. This is the first report describing the distribution of HPV intratype lineages of high and low oncogenic risk in asymptomatic women from southern Brazil.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Papillomaviridae
/
Vaginal Smears
/
DNA, Viral
/
Uterine Cervical Diseases
/
Genome, Viral
/
Papillomavirus Infections
Type of study:
Etiology study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2017
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Rio Grande/BR
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