Cytotoxic activity in cutaneous leishmaniasis
Mem. Inst. Oswaldo Cruz
;
112(11): 733-740, Nov. 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-894850
ABSTRACT
Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Killer Cells, Natural
/
T-Lymphocytes, Cytotoxic
/
Leishmaniasis, Cutaneous
/
CD8-Positive T-Lymphocytes
/
Cytotoxicity, Immunologic
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2017
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal da Bahia/BR
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