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Cytotoxic activity in cutaneous leishmaniasis
Campos, Taís M; Costa, Rúbia; Passos, Sara; Carvalho, Lucas P.
  • Campos, Taís M; Universidade Federal da Bahia. Serviço de Imunologia. Salvador. BR
  • Costa, Rúbia; Universidade Federal da Bahia. Serviço de Imunologia. Salvador. BR
  • Passos, Sara; Universidade Federal da Bahia. Serviço de Imunologia. Salvador. BR
  • Carvalho, Lucas P; Universidade Federal da Bahia. Serviço de Imunologia. Salvador. BR
Mem. Inst. Oswaldo Cruz ; 112(11): 733-740, Nov. 2017. tab, graf
Article in English | LILACS | ID: biblio-894850
ABSTRACT
Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.
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Full text: Available Index: LILACS (Americas) Main subject: Killer Cells, Natural / T-Lymphocytes, Cytotoxic / Leishmaniasis, Cutaneous / CD8-Positive T-Lymphocytes / Cytotoxicity, Immunologic Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2017 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Federal da Bahia/BR

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Full text: Available Index: LILACS (Americas) Main subject: Killer Cells, Natural / T-Lymphocytes, Cytotoxic / Leishmaniasis, Cutaneous / CD8-Positive T-Lymphocytes / Cytotoxicity, Immunologic Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2017 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Federal da Bahia/BR