Your browser doesn't support javascript.
loading
Correlation between the BACTEC MGIT 960 culture system with Genotype MTBDRplus and TB-SPRINT in multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil
Dantas, Nayanne Gama Teixeira; Suffys, Phillip Noel; Carvalho, Wânia da Silva; Gomes, Harrison Magdinier; Almeida, Isabela Neves de; Figueiredo, Lida Jouca de Assis; Gonçalves, Alan Douglas; Gomgnimbou, Michel Kireopori; Refregier, Guislaine; Sola, Christophe; Miranda, Silvana Spíndola de.
  • Dantas, Nayanne Gama Teixeira; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte. BR
  • Suffys, Phillip Noel; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte. BR
  • Carvalho, Wânia da Silva; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte. BR
  • Gomes, Harrison Magdinier; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte. BR
  • Almeida, Isabela Neves de; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte. BR
  • Figueiredo, Lida Jouca de Assis; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte. BR
  • Gonçalves, Alan Douglas; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte. BR
  • Gomgnimbou, Michel Kireopori; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte. BR
  • Refregier, Guislaine; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte. BR
  • Sola, Christophe; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte. BR
  • Miranda, Silvana Spíndola de; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte. BR
Mem. Inst. Oswaldo Cruz ; 112(11): 769-774, Nov. 2017. tab
Article in English | LILACS | ID: biblio-894852
ABSTRACT
BACKGROUND The accurate detection of multidrug-resistant tuberculosis (MDR-TB) is critical for the application of appropriate patient treatment and prevention of transmission of drug-resistant Mycobacterium tuberculosis isolates. The goal of this study was to evaluate the correlation between phenotypic and molecular techniques for drug-resistant tuberculosis diagnostics. Molecular techniques used were the line probe assay genotype MTBDRplus and the recently described tuberculosis-spoligo-rifampin-isoniazid typing (TB-SPRINT) bead-based assay. Conventional drug susceptibility testing (DST) was done on a BACTECTM MGIT 960 TB. METHOD We studied 80 M. tuberculosis complex (MTC) clinical isolates from Minas Gerais state, of which conventional DST had classified 60 isolates as MDR and 20 as drug susceptible. FINDINGS Among the 60 MDR-TB isolates with MGIT as a reference, sensitivity, specificity, accuracy, and kappa for rifampicin (RIF) resistance using TB-SPRINT and MTBDRplus, were 96.7% versus 93.3%, 100.0% versus 100.0%, 97.5% versus 95.0% and 0.94 versus 0.88, respectively. Similarly, the sensitivity, specificity, accuracy, and kappa for isoniazid (INH) resistance were 85.0% and 83.3%, 100.0% and 100.0%, 88.8% and 87.5% and 0.74 and 0.71 for both tests, respectively. Finally, the sensitivity, specificity, accuracy, and kappa for MDR-TB were 85.0% and 83.3%, 100.0% and 100.0%, 88.8% and 87.5% and 0.74 and 0.71 for both tests, respectively. MAIN CONCLUSIONS Both methods exhibited a good correlation with the conventional DST. We suggest estimating the cost-effectiveness of MTBDRplus and TB-SPRINT in Brazil.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Bacteriological Techniques / Tuberculosis, Multidrug-Resistant / Mycobacterium tuberculosis Type of study: Diagnostic study Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2017 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Bacteriological Techniques / Tuberculosis, Multidrug-Resistant / Mycobacterium tuberculosis Type of study: Diagnostic study Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2017 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR