RNA viruses in trypanosomatid parasites: a historical overview
Mem. Inst. Oswaldo Cruz
;
113(4): e170487, 2018. graf
Article
in English
| LILACS
| ID: biblio-894910
ABSTRACT
Viruses of trypanosomatids are now being extensively studied because of their diversity and the roles they play in flagellates' biology. Among the most prominent examples are leishmaniaviruses implicated in pathogenesis of Leishmania parasites. Here, we present a historical overview of this field, starting with early reports of virus-like particles on electron microphotographs, and culminating in detailed molecular descriptions of viruses obtained using modern next generation sequencing-based techniques. Because of their diversity, different life cycle strategies and host specificity, we believe that trypanosomatids are a fertile ground for further explorations to better understand viral evolution, routes of transitions, and molecular mechanisms of adaptation to different hosts.
Full text:
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Index:
LILACS (Americas)
Main subject:
RNA Viruses
/
Trypanosomatina
/
Microscopy, Electron, Scanning Transmission
/
Leishmaniavirus
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2018
Type:
Article
/
Project document
Affiliation country:
Czech Republic
Institution/Affiliation country:
University of Ostrava/CZ
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