The war on cryptococcosis: A Review of the antifungal arsenal
Mem. Inst. Oswaldo Cruz
;
113(7): e170391, 2018.
Article
in English
| LILACS
| ID: biblio-894941
ABSTRACT
Cryptococcal meningitis is the most common central nervous system infection in the world today. It occurs primarily, but not exclusively, in immunocompromised individuals and despite substantial improvement in management of clinical events like AIDS, the numbers of cases of cryptococcosis remain very high. Unfortunately, despite several antifungal agents available for treatment, morbidity and mortality rates remain high with this fungal infection. In this Review, we will describe the treatments and strategies for success, identify the failures, and provide insights into the future developments / improvements for management. This sugar-coated yeast can play havoc within the human brain. Our goals must be to either prevent or diagnose disease early and treat aggressively with all our clinical tools when disease is detected.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Meningitis, Cryptococcal
/
AIDS-Related Opportunistic Infections
/
Antifungal Agents
Limits:
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2018
Type:
Article
Affiliation country:
United States
Institution/Affiliation country:
Duke University/US
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