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The war on cryptococcosis: A Review of the antifungal arsenal
Mourad, Ahmad; Perfect, John R.
  • Mourad, Ahmad; Duke University. Medical Center. Department of Medicine. Durham. US
  • Perfect, John R; Duke University. Medical Center. Department of Medicine. Durham. US
Mem. Inst. Oswaldo Cruz ; 113(7): e170391, 2018.
Article in English | LILACS | ID: biblio-894941
ABSTRACT
Cryptococcal meningitis is the most common central nervous system infection in the world today. It occurs primarily, but not exclusively, in immunocompromised individuals and despite substantial improvement in management of clinical events like AIDS, the numbers of cases of cryptococcosis remain very high. Unfortunately, despite several antifungal agents available for treatment, morbidity and mortality rates remain high with this fungal infection. In this Review, we will describe the treatments and strategies for success, identify the failures, and provide insights into the future developments / improvements for management. This sugar-coated yeast can play havoc within the human brain. Our goals must be to either prevent or diagnose disease early and treat aggressively with all our clinical tools when disease is detected.
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Full text: Available Index: LILACS (Americas) Main subject: Meningitis, Cryptococcal / AIDS-Related Opportunistic Infections / Antifungal Agents Limits: Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2018 Type: Article Affiliation country: United States Institution/Affiliation country: Duke University/US

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Full text: Available Index: LILACS (Americas) Main subject: Meningitis, Cryptococcal / AIDS-Related Opportunistic Infections / Antifungal Agents Limits: Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2018 Type: Article Affiliation country: United States Institution/Affiliation country: Duke University/US