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Acute melatonin administration enhances aerobic tolerance: an analysis of biochemical and hematological parameters
Beck, Wladimir Rafael; Messias, Leonardo Henrique Dalcheco; Silva, Franciele Carneiro da; Manchado-Gobatto, Fúlvia Barros; Gobatto, Claudio Alexandre.
  • Beck, Wladimir Rafael; Faculdade Einstein de Limeira. Limeira. BR
  • Messias, Leonardo Henrique Dalcheco; Universidade Estadual de Campinas - UNICAMP. School of Applied Sciences. Campinas. BR
  • Silva, Franciele Carneiro da; Faculdade Einstein de Limeira. Limeira. BR
  • Manchado-Gobatto, Fúlvia Barros; Universidade Estadual de Campinas - UNICAMP. Campinas. BR
  • Gobatto, Claudio Alexandre; Universidade Estadual de Campinas - UNICAMP. Campinas. BR
Motriz (Online) ; 24(2): e1018169, 2018. tab, graf
Article in English | LILACS | ID: biblio-895063
ABSTRACT

Aims:

This study is aimed at testing the acute melatonin administration (oral; 6 mg) on aerobic tolerance at cycloergometer and analyzing the consequences on biochemical and hematological parameters.

Methods:

The maximal aerobic capacity intensity (iMAC) at cycloergometer of eleven male healthy men (24.18±3.92 years-old; 87.07±12.48 kg; 1.82±0.05 m; 26.18±3.63 kg/m2; and 16.28±5.77 % of fat) was individually determined and used to perform a time to exhaustion (tlim) trial of 30 minutes after melatonin or placebo administration. We observed 48-72h interval between tests, performed in a double-blind experiment design. In order to determine hematological and biochemical parameters we collected venous blood samples before and after tlim. Statistical significance was set at 5%. Results The intensity and the lactatemia corresponding to the maximal aerobic capacity were 120.88±18.78 W and 3.32±1.03 mmol.L-1, respectively. The tlim with placebo (33.94±15.26 min, confidence interval = 24.92 - 42.95) was significantly lower than the tlim with melatonin (41.94±17.22 min; CI = 31.76 - 52.12; p = 0.03; 19.06%; effect size = 0.49). All of the 21 analyzed blood physiological variables resulted in no significant variation after tlim when placebo was compared to melatonin, except for total sera cholesterol (lower after exercise with melatonin).

Conclusion:

Acute melatonin administration enhanced aerobic tolerance at iMAC in 19% at cycloergometer; however, the biochemical and hematological variables assessed were not significantly modulated.(AU)
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Oxygen Consumption / Exercise / 5-Methoxytryptamine / Vital Capacity / Melatonin Type of study: Controlled clinical trial Limits: Adult / Humans / Male Language: English Journal: Motriz (Online) Journal subject: Educa‡Æo F¡sica e Treinamento / Medicina Esportiva / Medicina F¡sica e Reabilita‡Æo Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade Einstein de Limeira/BR / Universidade Estadual de Campinas - UNICAMP/BR

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Full text: Available Index: LILACS (Americas) Main subject: Oxygen Consumption / Exercise / 5-Methoxytryptamine / Vital Capacity / Melatonin Type of study: Controlled clinical trial Limits: Adult / Humans / Male Language: English Journal: Motriz (Online) Journal subject: Educa‡Æo F¡sica e Treinamento / Medicina Esportiva / Medicina F¡sica e Reabilita‡Æo Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade Einstein de Limeira/BR / Universidade Estadual de Campinas - UNICAMP/BR