Association between the RAGE (receptor for advanced glycation end-products) -374T/A gene polymorphism and diabetic retinopathy in T2DM
Rev. Assoc. Med. Bras. (1992)
;
63(11): 971-977, Nov. 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-896309
ABSTRACT
Summary Objective:
Interaction between advanced glycation end-products (AGEs) and receptor for AGEs (RAGE) in cells could affect both extracellular and intracellular structure and function, which plays a pivotal role in diabetic microvascular complications. The results from previous epidemiological studies on the association between RAGE gene -374T/A polymorphism and diabetic retinopathy (DR) risk were inconsistent. Thus, we conducted this meta-analysis to summarize the possible association between RAGE -374T/A polymorphism and DR risk.Method:
We searched all relevant articles on the association between RAGE -374T/A polymorphism and DR risk from PubMed, Cochrane Library, ScienceDirect, Wanfang, VIP and Chinese National Knowledge Infrastructure (CNKI) web databases up to August 2016. Odds ratio (OR) with 95% confidence interval (CI) were calculated to assess those associations. All analyses were performed using the Review Manager software.Results:
Nine case-control studies, including 1,705 DR cases and 2,236 controls were enrolled, and the results showed that the A allele of RAGE -374T/A polymorphism was significantly associated with increased DR risk in dominant model (TA/AA vs. TT OR=1.22, 95CI 1.05-1.41, p=0.006) and heterozygote model (TA vs. TT OR=1.26, 95CI 1.07-1.47, p=0.005). The subgroup analysis by ethnicity showed that significantly increased DR risk was found in both Asian and Caucasian populations.Conclusion:
This meta-analysis reveals that the A allele of RAGE -374T/A polymorphism probably increase DR risk.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Diabetes Mellitus, Type 2
/
Diabetic Retinopathy
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992)
Year:
2017
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Kunming University of Science and Technology/CN
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