Systemic administration of curcumin nanoparticles protects ischemia-reperfusion injury in ovaries: An animal model study
Rev. Assoc. Med. Bras. (1992, Impr.)
; 64(1): 22-31, Jan. 2018. tab, graf
Article
in En
| LILACS
| ID: biblio-896419
Responsible library:
BR1.1
ABSTRACT
Summary Objective:
Ovarian torsion must be diagnosed and treated as early as possible. The aim of the present study was to investigate the effects of intraperitoneal administration of nanocurcumin on ischemia-reperfusion injury in ovaries.Method:
Thirty-five (35) healthy female Wistar rats weighing approximately 250 g were randomized into seven experimental groups (n=5) Group SSG - The rats underwent only laparotomy. Group I A 3-hour ischemia only. Group I/R A 3-hour ischemia and 3-hour reperfusion. Group I/C A 3-hour ischemia only, and 1 mg/kg intraperitoneal administration of curcumin 2.5 hours after induction of ischemia. Group I/R/C A 3-hour ischemia, 3-hour reperfusion, and 1 mg/kg intraperitoneal administration of curcumin 2.5 hours after induction of ischemia. Group I/NC A 3-hour ischemia only and 1 mg/kg intraperitoneal administration of nanocurcumin 2.5 hours after induction of ischemia. Group I/R/C A 3-hour ischemia, 3-hour reperfusion and 1 mg/kg intraperitoneal administration of nanocurcumin 2.5 hours after induction of ischemia.Results:
Nanocurcumin-treated animals showed significantly improved development of ischemia and reperfusion tissue injury compared to those in the other groups (p<0.05). Significant higher values of SOD, tGSH, GPO, GSHRd and GST were observed in I/R/NC animals compared to those in the other groups (p<0.05). The damage indicators (NOS, MDA, MPO and DNA damage level) were significantly lower in I/R/NC animal compared to those of other groups (p<0.05).Conclusion:
Intraperitoneal administration of nanocurcumin can be helpful in minimizing ischemia-reperfusion injury in ovarian tissue exposed to ischemia.Key words
Full text:
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Index:
LILACS
Main subject:
Ovary
/
Reperfusion Injury
/
Curcumin
/
Nanoparticles
/
Ischemia
/
Antioxidants
Type of study:
Clinical_trials
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Rev. Assoc. Med. Bras. (1992, Impr.)
Journal subject:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
MEDICINA
Year:
2018
Type:
Article