Your browser doesn't support javascript.
loading
Perioperative synbiotics administration decreases postoperative infections in patients with colorectal cancer: a randomized, double-blind clinical trial / A administração perioperatória de simbióticos em pacientes com câncer colorretal reduz a incidência de infecções pós-operatórias: ensaio clínico randomizado duplo-cego
Flesch, Aline Taborda; Tonial, Stael T; Contu, Paulo de Carvalho; Damin, Daniel C.
  • Flesch, Aline Taborda; Federal University of Rio Grande do Sul. Post-Graduation Program in Surgical Sciences. Porto Alegre. BR
  • Tonial, Stael T; Federal University of Rio Grande do Sul. Post-Graduation Program in Surgical Sciences. Porto Alegre. BR
  • Contu, Paulo de Carvalho; Federal University of Rio Grande do Sul. Post-Graduation Program in Surgical Sciences. Porto Alegre. BR
  • Damin, Daniel C; Federal University of Rio Grande do Sul. Post-Graduation Program in Surgical Sciences. Porto Alegre. BR
Rev. Col. Bras. Cir ; 44(6): 567-573, Nov.-Dec. 2017. tab
Article in English | LILACS | ID: biblio-896634
ABSTRACT
ABSTRACT

Objective:

to evaluate the effect of perioperative administration of symbiotics on the incidence of surgical wound infection in patients undergoing surgery for colorectal cancer.

Methods:

We conducted a randomized clinical trial with colorectal cancer patients undergoing elective surgery, randomly assigned to receive symbiotics or placebo for five days prior to the surgical procedure and for 14 days after surgery. We studied 91 patients, 49 in the symbiotics group (Lactobacillus acidophilus 108 to 109 CFU, Lactobacillus rhamnosus 108 to 109 CFU, Lactobacillus casei 108 to 109 CFU, Bifi dobacterium 108 to 109 CFU and fructo-oligosaccharide (FOS) 6g) and 42 in the placebo group.

Results:

surgical site infection occurred in one (2%) patient in the symbiotics group and in nine (21.4%) patients in the control group (p=0.002). There were three cases of intraabdominal abscess and four cases of pneumonia in the control group, whereas we observed no infections in patients receiving symbiotics (p=0.001).

Conclusion:

the perioperative administration of symbiotics significantly reduced postoperative infection rates in patients with colorectal cancer. Additional studies are needed to confirm the role of symbiotics in the surgical treatment of colorectal cancer.
RESUMO
RESUMO

Objetivo:

avaliar o efeito da administração perioperatória de simbióticos na incidência de infecção de ferida operatória em pacientes operados por câncer colorretal.

Métodos:

ensaio clínico randomizado de pacientes com câncer colorretal submetidos à cirurgia eletiva e aleatoriamente designados para receberem simbióticos ou placebo por cinco dias antes do procedimento cirúrgico e por 14 dias após a cirurgia. Noventa e um pacientes foram estudados 49 para o grupo de simbióticos (Lactobacillus acidophilus 108 a 109 UFC, Lactobacillus rhamnosus 108 a 109 UFC, Lactobacillus casei 108 a 109 UFC, Bifi dobacterium 108 a 109 UFC e fruto-oligosacarídeos (FOS) 6g) e 42 para o grupo placebo.

Resultados:

infecção de sítio cirúrgico ocorreu em um (2%) paciente no grupo de simbióticos e em nove (21,4%) pacientes no grupo controle (p=0,002). Três casos de abscesso intra-abdominal e quatro casos de pneumonia foram diagnosticados no grupo controle, enquanto não foram observadas tais infecções em pacientes que receberam simbióticos (p=0,001).

Conclusão:

a administração perioperatória de simbióticos reduziu significativamente as taxas de infecção pós-operatória em pacientes com câncer colorretal. Estudos adicionais são necessários para confirmar o papel dos simbióticos no tratamento cirúrgico do câncer colorretal.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Surgical Wound Infection / Colorectal Neoplasms / Perioperative Care / Synbiotics Type of study: Controlled clinical trial / Incidence study / Prognostic study / Risk factors / Screening study Limits: Female / Humans / Male Language: English Journal: Rev. Col. Bras. Cir Journal subject: General Surgery Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Rio Grande do Sul/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Surgical Wound Infection / Colorectal Neoplasms / Perioperative Care / Synbiotics Type of study: Controlled clinical trial / Incidence study / Prognostic study / Risk factors / Screening study Limits: Female / Humans / Male Language: English Journal: Rev. Col. Bras. Cir Journal subject: General Surgery Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Rio Grande do Sul/BR