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Evaluation of the effects of atorvastatin and ischemic postconditioning preventing on the ischemia and reperfusion injury: experimental study in rats
Pontes, Henrique Budib Dorsa; Pontes, José Carlos Dorsa Vieira; Azevedo Neto, Euler de; Vendas, Giovanna Serra da Cruz; Miranda, João Victor Cunha; Dias, Letícia do Espírito Santos; Oliva, João Victor Durães Gomes; Almeida, Murilo Henrique Martins de; Chaves, Ian de Oliveira; Sampaio, Tricia Luna; Santos, Carlos Henrique Marques dos; Dourado, Doroty Mesquita.
  • Pontes, Henrique Budib Dorsa; Universidade Anhanguera. Campo Grande. BR
  • Pontes, José Carlos Dorsa Vieira; Universidade Anhanguera. Campo Grande. BR
  • Azevedo Neto, Euler de; Universidade Anhanguera. Campo Grande. BR
  • Vendas, Giovanna Serra da Cruz; Universidade Anhanguera. Campo Grande. BR
  • Miranda, João Victor Cunha; Universidade Anhanguera. Campo Grande. BR
  • Dias, Letícia do Espírito Santos; Universidade Anhanguera. Campo Grande. BR
  • Oliva, João Victor Durães Gomes; Universidade Anhanguera. Campo Grande. BR
  • Almeida, Murilo Henrique Martins de; Universidade Anhanguera. Campo Grande. BR
  • Chaves, Ian de Oliveira; Universidade Anhanguera. Campo Grande. BR
  • Sampaio, Tricia Luna; Universidade Anhanguera. Campo Grande. BR
  • Santos, Carlos Henrique Marques dos; Universidade Anhanguera. Campo Grande. BR
  • Dourado, Doroty Mesquita; Universidade Anhanguera. Campo Grande. BR
Rev. bras. cir. cardiovasc ; 33(1): 72-81, Jan.-Feb. 2018. tab, graf
Article in English | LILACS | ID: biblio-897980
Responsible library: BR1.1
ABSTRACT
Abstract

Introduction:

Reperfusion injury leads to systemic morphological and functional pathological alterations. Some techniques are already estabilished to attenuate the damage induced by reperfusion. Ischemic preconditioning is one of the standard procedures. In the last 20 years, several experimental trials demonstrated that the ischemic postconditioning presents similar effectiveness. Recently experimental trials demonstrated that statins could be used as pharmacological preconditioning.

Methods:

41 Wistar rats (Rattus norvegicus albinus) were distributed in 5 groups Ischemia and Reperfusion (A), Ischemic Postconditioning (B), Statin (C), Ischemic Postconditioning + Statins (D) and SHAM (E). After euthanasia, lungs, liver, kidneys and ileum were resected and submitted to histopathological analysis.

Results:

The average of lung parenchymal injury was A=3.6, B=1.6, C=1.2, D=1.2, E=1 (P=0.0029). The average of liver parenchymal injury was A=3, B=1.5, C=1.2, D=1.2, E = 0 (P<0.0001). The average of renal parenchymal injury was A=4, B=2.44, C=1.22, D=1.11, E=1 (P<0.0001). The average of intestinal parenchymal injury was A=2, B=0.66, C=0, D=0, E=0 (P=0.0006). The results were submitted to statistics applying Kruskal-Wallis test, estabilishing level of significance P<0.05.

Conclusion:

Groups submitted to ischemic postconditioning, to pre-treatment with statins and both methods associated demonstrated less remote reperfusion injuries, compared to the group submitted to ischemia and reperfusion without protection.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Reperfusion Injury / Ischemic Preconditioning / Ischemic Postconditioning / Atorvastatin Type of study: Controlled clinical trial Limits: Animals Language: English Journal: Rev. bras. cir. cardiovasc Journal subject: Cardiology / General Surgery Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Anhanguera/BR

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Full text: Available Index: LILACS (Americas) Main subject: Reperfusion Injury / Ischemic Preconditioning / Ischemic Postconditioning / Atorvastatin Type of study: Controlled clinical trial Limits: Animals Language: English Journal: Rev. bras. cir. cardiovasc Journal subject: Cardiology / General Surgery Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Anhanguera/BR