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Cytotoxic diterpenoids from the roots of Salvia lachnocalyx
Mirzaei, Hossein Hadavand; Firuzi, Omidreza; Schneider, Bernd; Baldwin, Ian T.; Jassbi, Amir Reza.
  • Mirzaei, Hossein Hadavand; Shiraz University of Medical Sciences. Medicinal and Natural Products Chemistry Research Center. Shiraz. IR
  • Firuzi, Omidreza; Shiraz University of Medical Sciences. Medicinal and Natural Products Chemistry Research Center. Shiraz. IR
  • Schneider, Bernd; Shiraz University of Medical Sciences. Medicinal and Natural Products Chemistry Research Center. Shiraz. IR
  • Baldwin, Ian T.; Shiraz University of Medical Sciences. Medicinal and Natural Products Chemistry Research Center. Shiraz. IR
  • Jassbi, Amir Reza; Shiraz University of Medical Sciences. Medicinal and Natural Products Chemistry Research Center. Shiraz. IR
Rev. bras. farmacogn ; 27(4): 475-479, July-Aug. 2017. tab, graf
Article in English | LILACS | ID: biblio-898689
ABSTRACT
ABSTRACT Salvia lachnocalyx Hedge, Lamiaceae, is an endemic sage which grows naturally in the Fars Province of Iran. The phytochemical analyses of the roots of S. lachnocalyx led to the isolation of five known diterpenoids ferruginol (1), taxodione (2), sahandinone (3), 4-dehydrosalvilimbinol (4) and labda-7,14-dien-13-ol (5). Their chemical structures were elucidated using one (1H and 13C) and two dimensional (COSY, HSQC and HMBC) NMR spectroscopic data as well as electron impact mass spectra. The cytotoxicity of the purified compounds was evaluated against three human cancer cell lines; MOLT-4 (acute lymphoblastic leukemia), HT-29 (colorectal adenocarcinoma) and MCF7 (breast adenocarcinoma) and all of the isolated compounds showed considerable cytotoxic activity against these cell lines. Compounds 2 and 3 (IC50 range 0.41-3.87 µg/ml) with endocyclic α,β-unsaturated carbonyl functional group, exhibited the highest cytotoxic activities compared to the other compounds (IC50 range 6.85-17.23 µg/ml). In conclusion, compounds 2 and 3 are presented as compounds that deserve further investigation of their biological activities.


Full text: Available Index: LILACS (Americas) Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2017 Type: Article / Project document Affiliation country: Iran Institution/Affiliation country: Shiraz University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2017 Type: Article / Project document Affiliation country: Iran Institution/Affiliation country: Shiraz University of Medical Sciences/IR