HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seeds

Castañeda-Gómez, Jhon; Rosas-Ramírez, Daniel; Cruz-Morales, Sara; Fragoso-Serrano, Mabel; Pereda-Miranda, Rogelio

Castañeda-Gómez, Jhon; Rosas-Ramírez, Daniel; Cruz-Morales, Sara; Fragoso-Serrano, Mabel; Pereda-Miranda, Rogelio.

Castañeda-Gómez, Jhon; Universidad Surcolombiana. Facultad de Educación. Programa de Licenciatura en Ciencias. Neiva. CO
Rosas-Ramírez, Daniel; Universidad Surcolombiana. Facultad de Educación. Programa de Licenciatura en Ciencias. Neiva. CO
Cruz-Morales, Sara; Universidad Surcolombiana. Facultad de Educación. Programa de Licenciatura en Ciencias. Neiva. CO
Fragoso-Serrano, Mabel; Universidad Surcolombiana. Facultad de Educación. Programa de Licenciatura en Ciencias. Neiva. CO
Pereda-Miranda, Rogelio; Universidad Surcolombiana. Facultad de Educación. Programa de Licenciatura en Ciencias. Neiva. CO

Rev. bras. farmacogn ; 27(4): 434-439, July-Aug. 2017. tab, graf

Article in English | LILACS | ID: biblio-898695

ABSTRACT

ABSTRACT

ABSTRACT High performance liquid chromatography profiling with mass spectrometry detection was applicable to identify known and novel multidrug-resistance glycolipid inhibitors from the complex resin glycosides mixture of Ipomoea alba L., Convolvulaceae, seeds. Albinosides X and XI were purified by recycling liquid chromatography and their structural elucidation was accomplished by nuclear magnetic resonance. Albinoside XI exerted a strong potentiation of vinblastine susceptibility in multidrug-resistant human breast carcinoma cells.

Glycolipid; HPLC-MS profiling; Resin glycoside

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Full text: Available Index: LILACS (Americas) Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2017 Type: Article / Project document Affiliation country: Colombia Institution/Affiliation country: Universidad Surcolombiana/CO

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