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Sirtuin 1 Levels in Recurrent Implantation Failure / Níveis de sirtuína 1 em falhas recorrentes de implantação
Engin-Ustun, Yaprak; Ozgu-Erdinc, A. Seval; Caglayan, Emel Kiyak; Gulerman, Cavidan; Sarikaya, Esma; Aktulay, Ayla; Demirtas, Canan; Erkaya, Salim; Yilmaz, Nafiye.
  • Engin-Ustun, Yaprak; University of Health Sciences. Reproductive Endocrinology Department. Dr. Zekai Tahir Burak Health Practice Research Center. Ankara. TR
  • Ozgu-Erdinc, A. Seval; University of Health Sciences. Reproductive Endocrinology Department. Dr. Zekai Tahir Burak Health Practice Research Center. Ankara. TR
  • Caglayan, Emel Kiyak; University of Health Sciences. Reproductive Endocrinology Department. Dr. Zekai Tahir Burak Health Practice Research Center. Ankara. TR
  • Gulerman, Cavidan; University of Health Sciences. Reproductive Endocrinology Department. Dr. Zekai Tahir Burak Health Practice Research Center. Ankara. TR
  • Sarikaya, Esma; University of Health Sciences. Reproductive Endocrinology Department. Dr. Zekai Tahir Burak Health Practice Research Center. Ankara. TR
  • Aktulay, Ayla; University of Health Sciences. Reproductive Endocrinology Department. Dr. Zekai Tahir Burak Health Practice Research Center. Ankara. TR
  • Demirtas, Canan; University of Health Sciences. Reproductive Endocrinology Department. Dr. Zekai Tahir Burak Health Practice Research Center. Ankara. TR
  • Erkaya, Salim; University of Health Sciences. Reproductive Endocrinology Department. Dr. Zekai Tahir Burak Health Practice Research Center. Ankara. TR
  • Yilmaz, Nafiye; University of Health Sciences. Reproductive Endocrinology Department. Dr. Zekai Tahir Burak Health Practice Research Center. Ankara. TR
Rev. bras. ginecol. obstet ; 39(10): 541-544, Nov. 2017. tab
Article in English | LILACS | ID: biblio-898835
ABSTRACT
Abstract Sirtuin 1 has an important role in cellular processes, including apoptosis and cellular stress. The purpose of this study was to assess serum sirtuin 1 levels in women with recurrent implantation failure (RIF). In this cross-sectional study, we included 28 women with RIF, 29 healthy women who had conceived by in vitro fertilization (IVF), and 30 women with a 1-cycle failure of IVF as controls. Human serum nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin-1 (SIRT1/SIRT2L1) levels were detected using a commercial colorimetric kit. Recurrent implantation failure patients have higher sirtuin 1 levels than non-pregnant women and healthy pregnant women, but this difference did not reach statistical significance due to the low number of patients in our study. These higher sirtuin 1 levels may result from the inflammation imbalance of RIF patients. The only statistically significant correlation found was between age and sirtuin (r = 0.277, p = 0.009).
RESUMO
Resumo A sirtuína 1 tem importante função nos processos celulares, incluindo a apoptose e o estresse celular. O objetivo deste estudo é o de avaliar níveis de sirtuína 1 em mulheres com falhas recorrentes de implantação (FRI). Neste estudo cruzado, incluímos 28 mulheres com FRI, 29 mulheres saudáveis que deram à luz por fertilização in vitro (FIV) bem-sucedida, e 30 mulheres com 1 ciclo de FIV malsucedido como controle. Os níveis de sirtuína 1 em soro humano de desacetilase dependente de dinucleotídeo de nicotinamida adenina (DNA) (SIRT1/SIRT2L1) foram detectados usando um kit colorimétrico comercial. Pacientes com FRI tiveram níveis de sirtuína 1 superiores às pacientes grávidas e aos controles, mas esta diferença não atingiu significância estatística devido ao baixo número de pacientes envolvidos. Estes níveis mais altos de sirtuína 1 podem ser resultado da inflamação desigual em pacientes com FRI. A única correlação estatisticamente significante encontrada foi entre idade e sirtuína (r = 0,277, p = 0,009).
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Embryo Implantation / Sirtuin 1 Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans Language: English Journal: Rev. bras. ginecol. obstet Journal subject: Gynecology / Obstetrics Year: 2017 Type: Article Affiliation country: Turkey Institution/Affiliation country: University of Health Sciences/TR

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Full text: Available Index: LILACS (Americas) Main subject: Embryo Implantation / Sirtuin 1 Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans Language: English Journal: Rev. bras. ginecol. obstet Journal subject: Gynecology / Obstetrics Year: 2017 Type: Article Affiliation country: Turkey Institution/Affiliation country: University of Health Sciences/TR