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Qualitative Determination of Human Chorionic Gonadotropin in Vaginal Washings for the Early Diagnosis of Premature Rupture of Fetal Membranes / Determinação qualitativa de gonadotrofina coriônica humana no lavado vaginal para o diagnóstico precoce de ruptura prematura de membranas fetais
Dartibale, Camila Buziquia; Uchimura, Nelson Shozo; Nery, Luiz; Schumeish, Angelita Polato; Uchimura, Liza Yurie Teruya; Santana, Rosangela Getirana; Uchimura, Taqueco Teruya.
  • Dartibale, Camila Buziquia; Universidade Estadual de Maringá. Department of Medicine. Maringá. BR
  • Uchimura, Nelson Shozo; Universidade Estadual de Maringá. Department of Medicine. Maringá. BR
  • Nery, Luiz; Universidade Estadual de Maringá. Department of Medicine. Maringá. BR
  • Schumeish, Angelita Polato; Universidade Estadual de Maringá. Department of Medicine. Maringá. BR
  • Uchimura, Liza Yurie Teruya; Universidade Estadual de Maringá. Department of Medicine. Maringá. BR
  • Santana, Rosangela Getirana; Universidade Estadual de Maringá. Department of Medicine. Maringá. BR
  • Uchimura, Taqueco Teruya; Universidade Estadual de Maringá. Department of Medicine. Maringá. BR
Rev. bras. ginecol. obstet ; 39(7): 317-321, July 2017. tab
Article in English | LILACS | ID: biblio-898879
ABSTRACT
Abstract Purpose This study aimed to evaluate and validate the qualitative human chorionic gonadotropin β subunit (β-hCG) test of the vaginal fluid washings of pregnant women with premature rupture of fetal membranes (PROM). Methods Cross-sectional study of pregnant women between gestational weeks 24 and 39 who underwent consultations in one of our institutions. They were divided into two groups group A (pregnant women clinically diagnosed with PROM) and group B (pregnant women without loss of amniotic liquid). The patients were subjected to a vaginal fluid washing with 3 mL of saline solution, which was aspirated subsequently with the same syringe. The solution was immediately sent to the laboratory to perform the vaginal β-hCG test with cut-off points of 10 mIU/mL (β-hCG-10) and/or 25 mIU/mL (β-hCG-25). Results The β-hCG-10 test of the vaginal secretion was performed in 128 cases. The chi-squared test with Yates' correction showed a statistically significant difference between the 2 groups (p = 0.0225). The sensibility, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy parameters were 77.1%, 43.6%, 52.3%; 70.4%; and 58.6% respectively. The β-hCG-25 test of the vaginal washing was performed in 49 cases. The analysis by Fisher's exact test showed a statistically significant difference between the groups (p = 0.0175). The sensibility, specificity, PPV, NPV, and accuracy parameters were 44.4%, 87.1%, 66.6%; 72.9%; and 71.4% respectively. Conclusions The β-hCG-25 test showed better accuracy for the diagnosis of PROM, and can corroborate the early diagnosis of PROM because it is a simple and quick exam.
RESUMO
Resumo Objetivo Este estudo objetivou validar o exame qualitativo da subunidade β da gonadotrofina coriônica humana (β-hCG) em lavado vaginal de gestantes com ruptura prematura de membranas (RPM) fetais. Métodos Estudo transversal de gestantes com 24 a 39 semanas atendidas em um hospital de Maringá divididas em 2 grupos grupo A (clinicamente diagnosticadas com RPM) e grupo B (gestantes sem perda de liquido amniótico). As pacientes foram submetidas a lavado vaginal com 3 mL de soro fisiológico, que logo em seguida foi aspirado de volta na mesma seringa e imediatamente enviado ao laboratório para a realização do exame de β-hCG vaginal com pontos de corte de 10 mIU/mL (β-hCG-10) e/ ou 25 mIU/mL (β-hCG-25). Resultados O teste de β-hCG-10 na secreção vaginal foi realizado em 128 casos, e o teste do qui-quadrado com correção de Yates mostrou diferença significante entre os dois grupos (p = 0,0225). Os parâmetros de sensibilidade, especificidade, valor preditivo positivo (VPP), valor preditivo negativo (VPN) e acurácia foram respectivamente 77,1%; 43,6%; 52,3%; 70,4%; e 58,6%. O teste de β-hCG-25 na secreção vaginal foi realizado em 49 casos, e a análise pelo teste exato de Fisher mostrou diferença significativa entre os grupos (p = 0,0175). Os parâmetros de sensibilidade, especificidade, VPP, VPN e acurácia foram respectivamente 44,4%; 87,1%; 66,6%; 72,9%; e 71,4%. Conclusões O β-hCG-25 apresentou melhor acurácia para o diagnóstico de RPM, e pode corroborar o diagnóstico precoce de RPM por se tratar de um exame simples e rápido.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Fetal Membranes, Premature Rupture / Chorionic Gonadotropin, beta Subunit, Human Type of study: Diagnostic study / Observational study / Prevalence study / Prognostic study / Qualitative research / Risk factors / Screening study Language: English Journal: Rev. bras. ginecol. obstet Journal subject: Gynecology / Obstetrics Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Maringá/BR

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Full text: Available Index: LILACS (Americas) Main subject: Fetal Membranes, Premature Rupture / Chorionic Gonadotropin, beta Subunit, Human Type of study: Diagnostic study / Observational study / Prevalence study / Prognostic study / Qualitative research / Risk factors / Screening study Language: English Journal: Rev. bras. ginecol. obstet Journal subject: Gynecology / Obstetrics Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Maringá/BR