Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
39(3): 195-200, July-Sept. 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-899361
ABSTRACT
Objective:
To investigate plasma concentrations of S100B (a calcium-binding protein derived primarily from the glia) and inflammatory cytokines in children with autism and the relationship between S100B and cytokine concentrations.Methods:
Plasma levels of S100B, tumor necrosis factor alpha (TNF-α), interferon gamma, interleukin (IL)-1β, IL-4, IL-6, IL-10, and IL-17A were measured in 40 unmedicated children with autism and 35 normally developing healthy children. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS).Results:
Concentrations of both S100B and TNF-α were higher in children with autism before and after adjusting for a priori-selected confounders (age, sex, and body mass index). S100B concentrations were higher in children with severe autism compared to children with mild-moderate autism. However, this association remained as a trend after adjusting for confounders. S100B concentrations correlated positively with TNF-α concentrations.Conclusion:
Our findings showing an increase in peripheral concentrations of S100B and TNF-α provide limited support to the hypothesis about the roles of altered immune function and S100B in autism spectrum disorder (ASD). Studies of larger numbers of well-characterized individuals with ASD are needed to clarify the potential role of the immune system in the pathophysiology of this disorder.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tumor Necrosis Factor-alpha
/
S100 Calcium Binding Protein beta Subunit
/
Autism Spectrum Disorder
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2017
Type:
Article
Affiliation country:
United States
Institution/Affiliation country:
Yale University/US
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