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Inadequate pain relief among patients with primary knee osteoarthritis / Alívio inadequado da dor em pacientes com osteoartrite de joelho primária
Laires, Pedro A; Laíns, Jorge; Miranda, Luís C; Cernadas, Rui; Rajagopalan, Srini; Taylor, Stephanie D; Silva, José C.
  • Laires, Pedro A; Merck. Sharp & Dohme. Oeiras. PT
  • Laíns, Jorge; Merck. Sharp & Dohme. Oeiras. PT
  • Miranda, Luís C; Merck. Sharp & Dohme. Oeiras. PT
  • Cernadas, Rui; Merck. Sharp & Dohme. Oeiras. PT
  • Rajagopalan, Srini; Merck. Sharp & Dohme. Oeiras. PT
  • Taylor, Stephanie D; Merck. Sharp & Dohme. Oeiras. PT
  • Silva, José C; Merck. Sharp & Dohme. Oeiras. PT
Rev. bras. reumatol ; 57(3): 229-237, May-June 2017. tab, graf
Article in English | LILACS | ID: biblio-899416
ABSTRACT
ABSTRACT

Background:

Despite the widespread treatments for osteoarthritis (OA), data on treatment patterns, adequacy of pain relief, and quality of life are limited. The prospective multinational Survey of Osteoarthritis Real World Therapies (SORT) was designed to investigate these aspects.

Objectives:

To analyze the characteristics and the patient reported outcomes of the Portuguese dataset of SORT at the start of observation.

Methods:

Patients ≥50 years with primary knee OA who were receiving oral or topical analgesics were eligible. Patients were enrolled from seven healthcare centers in Portugal between January and December 2011. Pain and function were evaluated using the Brief Pain Inventory (BPI) and WOMAC. Quality of life was assessed using the 12-Item Short Form Health Survey (SF-12). Inadequate pain relief (IPR) was defined as a score >4/10 on item 5 of the BPI.

Results:

Overall, 197 patients were analyzed. The median age was 67.0 years and 78.2% were female. Mean duration of knee OA was 6.2 years. IPR was reported by 51.3% of patients. Female gender (adjusted odds ratio - OR 2.15 [95%CI 1.1, 4.5]), diabetes (OR 3.1 [95%CI 1.3, 7.7]) and depression (OR 2.24 [95%CI 1.2, 4.3]) were associated with higher risk of IPR. Patients with IPR reported worst outcomes in all dimensions of WOMAC (p < 0.001) and in all eight domains and summary components of SF-12 (p < 0.001).

Conclusions:

Our findings indicate that improvements are needed in the management of pain in knee OA in order to achieve better outcomes in terms of pain relief, function and quality of life.
RESUMO
RESUMO Antecedentes Apesar dos tratamentos muito difundidos para a osteoartrite (OA), dados sobre os padrões de tratamento, a adequação do alívio da dor e a qualidade de vida são limitados. O estudo multinacional prospectivo Survey of Osteoarthritis Real World Therapies (SORT) foi projetado para investigar esses aspectos.

Objetivos:

Analisar as características e os desfechos relatados pelo paciente do conjunto de dados português do Sort no início da observação.

Métodos:

Consideraram-se elegíveis os pacientes com 50 anos ou mais com OA de joelho primária que recebiam analgésicos orais ou tópicos. Os pacientes foram recrutados de sete centros de saúde de Portugal entre janeiro e dezembro de 2011. A dor e a função foram avaliadas pelo Brief Pain Inventory (BPI) e pelo WOMAC. A qualidade de vida foi avaliada com o 12-item Short Form Health Survey (SF-12). O alívio inadequado da dor (AID) foi definido como uma pontuação > 4/10 no item 5 do BPI.

Resultados:

Foram analisados 197 pacientes. A idade média foi de 67 anos e 78,2% eram do sexo feminino. A duração média da OA de joelho foi de 6,2 anos. O AID foi relatado por 51,3% dos pacientes. O sexo feminino (odds ratio ajustado - OR 2,15 [IC 95% 1,1-4,5]), o diabetes (OR = 3,1 [IC 95% 1,3-7,7]) e a depressão (OR 2,24 [IC 95% 1,2-4,3]) estiveram associados a um maior risco de AID. Os pacientes com AID relataram piores desfechos em todas as dimensões do Womac (p < 0,001) e em todos os oito domínios e nos dois componentes sumários do SF-12 (p < 0,001).

Conclusões:

Os resultados do presente estudo indicam que é necessário melhorar o manejo da dor na OA de joelho a fim de alcançar melhores desfechos em termos de alívio da dor, função e qualidade de vida.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Osteoarthritis, Knee / Analgesics Type of study: Diagnostic study / Observational study / Prevalence study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Rev. bras. reumatol Journal subject: Rheumatology Year: 2017 Type: Article Affiliation country: Portugal Institution/Affiliation country: Merck/PT

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Full text: Available Index: LILACS (Americas) Main subject: Osteoarthritis, Knee / Analgesics Type of study: Diagnostic study / Observational study / Prevalence study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Rev. bras. reumatol Journal subject: Rheumatology Year: 2017 Type: Article Affiliation country: Portugal Institution/Affiliation country: Merck/PT