Evolución del protocolo de trombolisis endovenosa en ataque cerebrovascular isquémico agudo / Intravenous thrombolysis for acute ischemic stroke. A four years experience in a Chilean public hospital
Rev. méd. Chile
;
145(4): 468-475, abr. 2017. tab
Article
in Spanish
| LILACS
| ID: biblio-902500
ABSTRACT
Background:
Intravenous thrombolysis (IVT) with alteplase (tissue plasminogen activator) is the standard pharmacological treatment in acute ischemic stroke (AIS), reducing disability in patients.Aim:
To report the results a thrombolysis protocol during four years in a regional public hospital. Material andMethods:
Data from 106 consecutive patients aged 68 ± 13 years (57% men) who were treated with IVT, from May 2012 until April 2016, was analyzed.Results:
The median door-to-needle time was 80 minutes (interquartile range = 57-113). The median National Institute of Health Stroke Scale (NIHSS) scores on admission and at discharge were was 11.5 and 5 points respectively. At discharge, 27% of hospitalized patients had a favorable outcome (n = 99), defined as having 0 to 1 points in the modified Rankin scale. Symptomatic intracerebral hemorrhage and mortality rates were 5.7 and 13.1%, respectively. The thrombolysis rate rose from 0.7% in 2012 to 6% in 2016.Conclusions:
The implementation of 24/7 neurology shifts in the Emergency Department allowed us to increase the amount and quality of IVT in our hospital, as measured by the rate of thrombolysis and by process indicators such as door-to-needle time.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Thrombolytic Therapy
/
Brain Ischemia
/
Stroke
/
Fibrinolytic Agents
Type of study:
Etiology study
/
Practice guideline
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2017
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de La Frontera/CL
Similar
MEDLINE
...
LILACS
LIS