Farmacogenómica como herramienta fundamental para la medicina personalizada: aplicaciones en la práctica clínica / Clinical applications of pharmacogenomics
Rev. méd. Chile
;
145(4): 483-500, abr. 2017. tab
Article
in English
| LILACS
| ID: biblio-902502
ABSTRACT
Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pharmacogenetics
/
Polymorphism, Genetic
/
Drug Administration Schedule
Limits:
Humans
Language:
English
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2017
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL
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