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Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study
Posselt, Rayana Taques; Coelho, Vinícius Nicolelli; Pigozzo, Danieli Cristina; Guerrer, Marcela Idalia; Fagundes, Marília da Cruz; Nisihara, Renato; Skare, Thelma Larocca.
  • Posselt, Rayana Taques; Faculdade Evangélica do Paraná. Medicine Department. Curitiba. BR
  • Coelho, Vinícius Nicolelli; Faculdade Evangélica do Paraná. Medicine Department. Curitiba. BR
  • Pigozzo, Danieli Cristina; Faculdade Evangélica do Paraná. Medicine Department. Curitiba. BR
  • Guerrer, Marcela Idalia; Faculdade Evangélica do Paraná. Medicine Department. Curitiba. BR
  • Fagundes, Marília da Cruz; Faculdade Evangélica do Paraná. Medicine Department. Curitiba. BR
  • Nisihara, Renato; Faculdade Evangélica do Paraná. Medicine Department. Curitiba. BR
  • Skare, Thelma Larocca; Faculdade Evangélica do Paraná. Medicine Department. Curitiba. BR
São Paulo med. j ; 135(6): 535-540, Nov.-Dec. 2017. tab
Article in English | LILACS | ID: biblio-904120
ABSTRACT
ABSTRACT

BACKGROUND:

Thyroid autoimmunity is more common in patients with rheumatic diseases than in healthy populations. The degree of association seems subject to influence from patients' geographical location. Here, we aimed to ascertain the prevalence of thyroid autoantibodies in a cohort of patients with systemic rheumatic disease and the degree of association between its presence and inflammatory activity. DESIGN AND

SETTING:

Cross-sectional observational study in a rheumatology unit.

METHODS:

301 patients with systemic lupus erythematosus (SLE), 210 with rheumatoid arthritis (RA), 58 with scleroderma (SSc) and 80 with spondyloarthritis (SpA) were studied regarding thyroid function (TSH and T4), anti-thyroglobulin (TgAb) and anti-thyroperoxidase (TPOab) and compared with 141 healthy controls. Disease activity in patients with rheumatic disease was assessed through appropriate indexes.

RESULTS:

There were more antithyroid antibodies in SLE patients with hypothyroidism (P = 0.01; odds ratio, OR 2.7; 95% confidence interval, CI 1.20-6.26) and in those without hypothyroidism (P = 0.06; OR 2.4; 95% CI 1.28-4.55) than in controls. SSc patients also showed P = 0.03 both with antithyroid antibodies and hypothyroidism (OR 3.4; 95% CI 1.06-10.80) and without hypothyroidism (OR 3.1; 95% CI 1.11-0.13). RA and SpA patients had the same prevalence as controls (P not significant). Presence of autoantibodies with and without hypothyroidism was not associated with the activity or functional indexes evaluated.

CONCLUSION:

SLE and SSc were associated with higher prevalence of thyroid autoantibodies in patients with and without hypothyroidism, unlike SpA and RA. There was no link between thyroid autoantibody presence and disease activity or functional impairment.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Autoantibodies / Autoimmune Diseases / Rheumatic Diseases / Iodide Peroxidase Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade Evangélica do Paraná/BR

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Full text: Available Index: LILACS (Americas) Main subject: Autoantibodies / Autoimmune Diseases / Rheumatic Diseases / Iodide Peroxidase Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade Evangélica do Paraná/BR