A study of pulmonary function in end-stage renal disease patients on hemodialysis: a cross-sectional study
São Paulo med. j
;
135(6): 568-572, Nov.-Dec. 2017. tab
Article
in English
| LILACS
| ID: biblio-904126
ABSTRACT
ABSTRACT BACKGROUND:
The aim here was to study acute effects of hemodialysis among end-stage renal disease (ESRD) patients. DESIGN ANDSETTING:
Prospective study in tertiary-level care center.METHODS:
Fifty ESRD patients undergoing hemodialysis were studied. Spirometric pulmonary function tests were performed before and after four-hour hemodialysis sessions.RESULTS:
The patients' average age was 45.8 ± 10.0 years; 64% were males and 64% had normal body mass index. Anemia (94%) and hypoalbuminemia (72%) were common. Diabetes mellitus (68%), hypertension (34%) and coronary artery disease (18%) were major comorbidities. Forty-five patients (90%) had been on hemodialysis for six months to three years. The patients' pre-dialysis mean forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) were below normal 45.8 ± 24.9% and 43.5 ± 25.9% of predicted, respectively. After hemodialysis, these increased significantly, to 51.1 ± 23.4% and 49.3 ± 25.5% of predicted, respectively (P < 0.01). The increase in mean FEV1/FVC, from 97.8 ± 20.8% to 99.3 ± 20.1% of predicted, was not significant (P > 0.05). The pre-dialysis mean forced expiratory flow 25-75% was 50.1 ± 31% and increased significantly, to 56.3 ± 31.6% of predicted (P < 0.05). The mean peak expiratory flow was below normal (43.8 ± 30.7%) and increased significantly, to 49.1 ± 29.9% of predicted (P < 0.05). Males and females showed similar directions of change after hemodialysis.CONCLUSIONS:
Pulmonary function abnormalities are common among ESRD patients. Comparison of pre and post-hemodialysis parameters showed significant improvements, but normal predicted values were still not achieved.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Renal Dialysis
/
Renal Insufficiency, Chronic
/
Kidney Failure, Chronic
/
Lung Diseases
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
São Paulo med. j
Journal subject:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicine
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Year:
2017
Type:
Article
Affiliation country:
India
Institution/Affiliation country:
Indira Gandhi Medical College/IN
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