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HIV-1 genetic diversity and resistance to antiretroviral drugs among pregnant women in Ribeirão Preto (SP), Brazil. Cross-sectional study
Pimenta, Ana Teresa Mancini; Correa, Isadora Alonso; Melli, Patricia Pereira dos Santos; Abduch, Renata; Duarte, Geraldo; Couto-Fernandez, José Carlos; Quintana, Silvana Maria.
  • Pimenta, Ana Teresa Mancini; Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP). Department of Gynecology and Obstetrics. Ribeirão Preto. BR
  • Correa, Isadora Alonso; Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP). Department of Gynecology and Obstetrics. Ribeirão Preto. BR
  • Melli, Patricia Pereira dos Santos; Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP). Department of Gynecology and Obstetrics. Ribeirão Preto. BR
  • Abduch, Renata; Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP). Department of Gynecology and Obstetrics. Ribeirão Preto. BR
  • Duarte, Geraldo; Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP). Department of Gynecology and Obstetrics. Ribeirão Preto. BR
  • Couto-Fernandez, José Carlos; Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP). Department of Gynecology and Obstetrics. Ribeirão Preto. BR
  • Quintana, Silvana Maria; Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP). Department of Gynecology and Obstetrics. Ribeirão Preto. BR
São Paulo med. j ; 136(2): 129-135, Mar.-Apr. 2018. tab, graf
Article in English | LILACS | ID: biblio-904150
ABSTRACT
ABSTRACT

BACKGROUND:

Increasing genetic diversity of HIV-1 and emergence of drug-resistant mutations may reduce the efficacy of antiretroviral therapy and prophylaxis that are used to prevent mother-to-child transmission. The aim of this study was to assess the genetic diversity and prevalence of drug-resistant mutations among HIV-infected pregnant women. DESIGN AND

SETTING:

Cross-sectional study at an outpatient clinic for infectious diseases within gynecology and obstetrics.

METHODS:

This study evaluated the dynamics of HIV-1 subtypes and the prevalence of transmitted and acquired drug-resistant mutations among 38 HIV-infected pregnant women (20 previously exposed to antiretroviral therapy and 18 naive), in Ribeirão Preto (SP), Brazil, between 2010 and 2011. Genotyping was performed by means of molecular sequencing of the protease and reverse transcriptase regions of the HIV-1 pol gene.

RESULTS:

Subtype B was identified in 84.2% of the samples, recombinant forms between B and F in 7.9%, subtype F1 in 5.3% and the recombinant form K/F in 2.6%. No mutation associated with transmitted drug resistance was detected in the samples from the naive pregnant women, whereas mutations associated with acquired drug resistance were found in 35.0% of the pregnant women previously exposed to antiretroviral therapy.

CONCLUSION:

The results showed that subtype B predominated, while there was low prevalence of sequences with transmitted drug resistance.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pregnancy Complications, Infectious / Genetic Variation / HIV Infections / HIV-1 / Anti-HIV Agents / Drug Resistance, Viral / Mutation Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Female / Humans / Pregnancy Country/Region as subject: South America / Brazil Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo (USP)/BR

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Full text: Available Index: LILACS (Americas) Main subject: Pregnancy Complications, Infectious / Genetic Variation / HIV Infections / HIV-1 / Anti-HIV Agents / Drug Resistance, Viral / Mutation Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Female / Humans / Pregnancy Country/Region as subject: South America / Brazil Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo (USP)/BR