Survival outcome among patients with Ewing's sarcoma of bones and joints: a population-based cohort study
São Paulo med. j
;
136(2): 116-122, Mar.-Apr. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-904155
ABSTRACT
ABSTRACT BACKGROUND:
The aim here was to elucidate the current survival condition of patients diagnosed with Ewing's sarcoma of the bones and joints and determine independent risk factors associated with the prognosis. DESIGN ANDSETTING:
Retrospective cohort study based on the Surveillance, Epidemiology and End Results (SEER) database in the United States.METHODS:
We identified 397 patients who were diagnosed with Ewing's sarcoma of the bones and joints between January 2004 and December 2013. The multivariate Cox proportional hazards model was used to determine factors associated with the risk of death by adjusting for various factors.RESULTS:
The one, two and five-year disease-specific survival rates were 89.08%, 78.08% and 62.47%, respectively. The factors related to death were age (≥ 18 years versus < 18 years; hazard ratio, HR = 1.77; 95% confidence interval, CI 1.38-2.31); tumor site (extremity versus spine and pelvis; HR = 2.03; 95% CI 1.31-2.62); tumor size (> 10 cm versus ≤ 10 cm; HR = 1.78; 95% CI 1.34-2.56); and type of treatment (surgery alone versus radiotherapy with surgery; HR = 0.51; 95% CI 0.38-0.89; or radiotherapy alone versus radiotherapy with surgery; HR = 1.61; 95% CI 1.10-2.39; or no treatment versus radiotherapy with surgery; HR = 1.86; 95% CI 1.23, 2.58).CONCLUSIONS:
Patients with Ewing's sarcoma showed poor survival in situations of age ≥ 18 years, tumor size > 10 cm, receiving radiotherapy alone and receiving no treatment. Patients undergoing surgery alone had better survival.
Full text:
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Index:
LILACS (Americas)
Main subject:
Sarcoma, Ewing
/
Bone Neoplasms
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
São Paulo med. j
Journal subject:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicine
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Year:
2018
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Wuhan University/CN
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