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Description of an in vivo oral mucosa HSV-1 infection model in mice
Bastidas Legarda, Leidy Y; Beltrán, Edgar O; Marín Gallón, Lina M; Castellanos, Jaime E; Bohórquez, Sonia P.
  • Bastidas Legarda, Leidy Y; National University of Colombia. School of Dentistry. Group of Basic and Applied Research in Dentistry. Bogota. CO
  • Beltrán, Edgar O; National University of Colombia. School of Dentistry. Group of Basic and Applied Research in Dentistry. Bogota. CO
  • Marín Gallón, Lina M; National University of Colombia. School of Dentistry. Group of Basic and Applied Research in Dentistry. Bogota. CO
  • Castellanos, Jaime E; El Bosque University. Laboratory of Virology. Bogota. CO
  • Bohórquez, Sonia P; National University of Colombia. School of Dentistry. Group of Basic and Applied Research in Dentistry. Bogota. CO
Acta odontol. latinoam ; 30(3): 109-112, 2017. ilus
Article in English | LILACS | ID: biblio-904928
ABSTRACT
In this work, we established an in vivo murine model of herpes simplex virus type 1 (HSV1) infection involving inoculation by scarification of the oral mucosain order to study its dissemination towards the trigeminal ganglion (TG). Both viral DNA and infectious virions were detected on the third day postinfection (p.i.). Viral proteins revealed by immunohistochemistry were mainly found at seven days p.i., when the latencyassociated transcript (LAT) was also detected. This model simulated the dissemination process of HSV1, which could be used to study herpes pathogenesis starting in the oral mucosa (AU)
RESUMEN
Con el propósito de estudiar la dispersión de del Herpes Simplex Virus tipo 1 (HSV1) desde la mucosa oral hasta los ganglios trigeminales, en el presente trabajo se estableció un modelo de infección en ratones, haciendo inoculación por escarificación en la mucosa oral. Tanto ADN viral como viriones infecciosos se detectaron en los ganglios trigeminales al dia 3 postinfección (p.i.). Las proteínas virales se detectaron principalmente al día 7 p.i. cuando los transcritos asociados a latencia también fueron encontrados. El modelo de infección simula adecuadamente el proceso de dispersión del HSV1 y puede ser usado para el estudio de la patogénesis por herpes después de la infección primaria en la mucosa oral (AU)
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Trigeminal Ganglion / Herpesvirus 1, Human / Mouth Mucosa Limits: Animals Country/Region as subject: South America / Colombia Language: English Journal: Acta odontol. latinoam Journal subject: Dentistry Year: 2017 Type: Article Affiliation country: Colombia Institution/Affiliation country: El Bosque University/CO / National University of Colombia/CO

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Full text: Available Index: LILACS (Americas) Main subject: Trigeminal Ganglion / Herpesvirus 1, Human / Mouth Mucosa Limits: Animals Country/Region as subject: South America / Colombia Language: English Journal: Acta odontol. latinoam Journal subject: Dentistry Year: 2017 Type: Article Affiliation country: Colombia Institution/Affiliation country: El Bosque University/CO / National University of Colombia/CO