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Unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapy
Kiggundu, Reuben; Nabeta, Henry W; Okia, Richard; Rhein, Joshua; Lukande, Robert.
  • Kiggundu, Reuben; Makerere University. Infectious Disease Institute. College of Health Sciences. Kampala. UG
  • Nabeta, Henry W; Makerere University. School of Medicine. College of Health Sciences. Kampala. UG
  • Okia, Richard; Makerere University. School of Medicine. College of Health Sciences. Kampala. UG
  • Rhein, Joshua; University of Minnesota. Department of Medicine. Minneapolis. US
  • Lukande, Robert; Makerere University. School of Biomedical Sciences. College of Health Sciences. Kampala. UG
Autops. Case Rep ; 6(4): 27-33, Oct.-Dec. 2016. ilus
Article in English | LILACS | ID: biblio-905080
Responsible library: BR26.7
ABSTRACT
Histoplasmosis is the most common endemic mycoses among HIV-infected people. Patients with suppressed cell immunity mainly due to HIV are at increased risk of disseminated disease. Dermatological manifestations of immune reconstitution inflammatory syndrome (IRIS) and cutaneous manifestations of histoplasmosis similar to an IRIS event have been previously described. We report the case of a 43-year-old male who presented with cutaneous disseminated histoplasmosis due to Histoplasma capsulatum var. capsulatum 4 months after the onset of the antiretroviral therapy and some improvement in the immune reconstitution. After 2 weeks of amphotericin B and itraconazole therapy, the scheduled treatment involved fluconazole maintenance therapy, which resulted in an improvement of his skin lesions.
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Full text: Available Index: LILACS (Americas) Main subject: Immune Reconstitution Inflammatory Syndrome / Histoplasmosis Type of study: Case report Limits: Adult / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2016 Type: Article Affiliation country: Uganda / United States Institution/Affiliation country: Makerere University/UG / University of Minnesota/US

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Full text: Available Index: LILACS (Americas) Main subject: Immune Reconstitution Inflammatory Syndrome / Histoplasmosis Type of study: Case report Limits: Adult / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2016 Type: Article Affiliation country: Uganda / United States Institution/Affiliation country: Makerere University/UG / University of Minnesota/US