Unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapy
Autops. Case Rep
;
6(4): 27-33, Oct.-Dec. 2016. ilus
Article
in English
| LILACS
| ID: biblio-905080
ABSTRACT
Histoplasmosis is the most common endemic mycoses among HIV-infected people. Patients with suppressed cell immunity mainly due to HIV are at increased risk of disseminated disease. Dermatological manifestations of immune reconstitution inflammatory syndrome (IRIS) and cutaneous manifestations of histoplasmosis similar to an IRIS event have been previously described. We report the case of a 43-year-old male who presented with cutaneous disseminated histoplasmosis due to Histoplasma capsulatum var. capsulatum 4 months after the onset of the antiretroviral therapy and some improvement in the immune reconstitution. After 2 weeks of amphotericin B and itraconazole therapy, the scheduled treatment involved fluconazole maintenance therapy, which resulted in an improvement of his skin lesions.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Immune Reconstitution Inflammatory Syndrome
/
Histoplasmosis
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Autops. Case Rep
Journal subject:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Year:
2016
Type:
Article
Affiliation country:
Uganda
/
United States
Institution/Affiliation country:
Makerere University/UG
/
University of Minnesota/US
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