Gelatinous transformation of bone marrow: rare or underdiagnosed?
Autops. Case Rep
;
7(4): 8-17, Oct.-Dec. 2017. tab, ilus
Article
in English
| LILACS
| ID: biblio-905366
ABSTRACT
Gelatinous transformation of the bone marrow (GTBM) is a rare hematologic entity, which was first described by Paul Michael in 1930. GTBM is mostly associated with caloric intake/anorexia nervosa, although it also has been described accompanying other pathologic conditions, such as malignancy, systemic lupus erythematosus and HIV infections. Even though the diagnostic features of the hematopoietic tissue, such as hypoplasia, adipose cell atrophy, and deposition of a gelatinous substance in the bone marrow (which stains with Alcian blue at pH 2.5) are quite specific, the underlying pathogenic mechanisms remain poorly understood. Considering the evidence of reversibilitynotably in cases of malnutrition and anorexiathis entity should be kept high on cards as a possible differential diagnosis of patients presenting with cytopenias and associated weight loss or starvation, especially in developing countries with nutritionally deprived populations. On an extensive review of the literature aimed at comprehensively addressing the evolution of the GTBM from the past century until now, we conclude that the lack of clinical suspicion and awareness regarding this pathologic entity has led to misdiagnosis and delayed diagnosis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Bone Marrow Diseases
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Autops. Case Rep
Journal subject:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Year:
2017
Type:
Article
Affiliation country:
India
Institution/Affiliation country:
Armed Forces Medical College/IN
/
Government Medical College/IN
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