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Studies of the antitrypanosomal and toxicological properties of Anogeissus leiocarpus (Dc.) Guill. & Perr. (Combretaceae) and Vitellaria paradoxa C. F. Gaertn (Sapotaceae) in mice / Estudios de las propiedades antitripanosómicas y toxicológicas de Anogeissus leiocarpus (Dc). Guill. & Perr. (Combretaceae) y Vitellaria paradoxa C. F. Gaertn (Sapotaceae) en ratones
Awokunlehin, Akintunde; Elusiyan, Christianah A; Bejide, Ronald A; Obuotor, Efere M; Adewunmi, Clement O.
  • Awokunlehin, Akintunde; Faculty of Pharmacy. Drug Research and Production Unit. NG
  • Elusiyan, Christianah A; Faculty of Pharmacy. Drug Research and Production Unit. NG
  • Bejide, Ronald A; Faculty of Clinical Sciences. Department of Morbid Anatomy and Forensic Medicine. NG
  • Obuotor, Efere M; Obafemi Awolowo University (OAU). Faculty of Science. Department of Biochemistry. NG
  • Adewunmi, Clement O; Faculty of Pharmacy. Drug Research and Production Unit. NG
Bol. latinoam. Caribe plantas med. aromát ; 14(2): 118-130, Mar. 2015. tab, graf, ilus
Article in English | LILACS | ID: biblio-907477
ABSTRACT
African animal trypanosomosis (AAT) is a disease of concern with ravaging effects on the health of both animals and livestock in tropical Africa. This study investigates the anti-trypanosomal activities of Anogeissus leiocarpus (ALE) and Vitelleria paradoxa (VPE) stem bark extracts and also determines the toxicological profile of the active plant, with a view to establishing the anti-trypanosomal potential and safety of the plants. Laboratory mice (19 g – 26 g) and rats (140 g – 165 g) obtained from the Animal house, Faculty of Pharmacy, OAU, Ile-Ife were used for the study. The animals were treated according to the standard set criteria for animal use and care. VPE showed neither trypanocidal nor trypanostatic activities while ALE was found to be trypanostatic at 62.5 and 125 mg/kg body weight. However, the partitioned aqueous fraction of ALE was found to demonstrate comparable anti-trypanocidal effect as Diminal (standard agent). In conclusion, the ethanolic extract of A. leiocarpus possesses antitrypanosomal effect through the relative suppression or delay in parasite establishment in trypanosome-infected mice. The toxicological study of A. leiocarpus stem bark extract revealed that it is relatively safe for use in cattle and other grazing animals.
RESUMEN
La tripanosomiasis africana de los animales es una enfermedad de preocupación que causa estragos sobre la salud de los animales y el ganado en África tropical. Este estudio investiga las actividades anti-tripanosomal de Anogeissus leiocarpus (ALE) y Vitelleria paradoxa (VPE) del tallo y extractos de corteza. También determina el perfil toxicológico de la planta activa, con el fin de establecer el potencial anti-tripanosomal y la seguridad de las plantas. Ratones de laboratorio (19 g - 26 g) y ratas (140 g - 165 g) obtenidos del Bioterio de la Facultad de Farmacia de la OUA, se utilizaron para el estudio. Los animales fueron tratados de acuerdo con los criterios estándar establecido para el uso y cuidado de animales. VPE mostró actividades no tripanocidas ni tripanostáticas mientras que en ALE se encontró que era tripanostático a 62,5 y 125 mg/kg de peso corporal. Sin embargo, se encontró que la fracción acuosa de ALE demostró un efecto anti-tripanocida comparable como Diminal (agente estándar). En conclusión, el extracto etanólico de A. leiocarpus posee efecto sobre tripanosomas a través de la supresión relativa o retraso en la creación de parásitos en ratones infectados con tripanosomosis. El estudio toxicológico del extracto de corteza del tallo A. leiocarpus reveló que es relativamente seguro para su uso en el ganado y otros animales de pastoreo.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Trypanocidal Agents / Trypanosomiasis, African / Plant Extracts / Combretaceae / Sapotaceae Limits: Animals Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2015 Type: Article / Project document Affiliation country: Nigeria Institution/Affiliation country: Faculty of Clinical Sciences/NG / Faculty of Pharmacy/NG / Obafemi Awolowo University (OAU)/NG

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Full text: Available Index: LILACS (Americas) Main subject: Trypanocidal Agents / Trypanosomiasis, African / Plant Extracts / Combretaceae / Sapotaceae Limits: Animals Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2015 Type: Article / Project document Affiliation country: Nigeria Institution/Affiliation country: Faculty of Clinical Sciences/NG / Faculty of Pharmacy/NG / Obafemi Awolowo University (OAU)/NG