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A study on genetic polymorphism in Matrix Metalloproteinases-3 in oral submucous fibrosis patients and in healthy individuals
Poonja, PA; Sattur, AP; Burde, KN; Hiremath, SV.
  • Poonja, PA; College of Dental Sciences-SDM. Department of Oral Medicine and Radiology. Sattur, Dharwad. IN
  • Sattur, AP; College of Dental Sciences and Hospital-SDM. Department of Oral Medicine and Radiology. Sattur, Dharwad. IN
  • Burde, KN; College of Dental Sciences and Hospital-SDM. Department of Oral Medicine and Radiology. Sattur, Dharwad. IN
  • Hiremath, SV; PC Jabin College. Department of Biotechnology. Dharwad, Karnataka. IN
Appl. cancer res ; 37: 1-12, 2017. tab, ilus
Article in English | LILACS, Inca | ID: biblio-910864
ABSTRACT

Background:

OSF is a potentially malignant condition affecting the oral cavity and oropharynx. MMP-3 also known as Stromelysin -I is a key member of the MMP family which is responsible for degradation of collagen type II,IV,V,IX and X, proteoglycans, gelatins, fibronectin, laminin and elastin. It plays an important role in activation of pro MMP-1 into the active form of MMP-1 in malignant tissues. MMP-3 expression is low in normal tissues but it is altered during tumour formation, where remodeling of ECM is required. Purpose of the study To assess the association of single-nucleotide polymorphisms, Adenosine (Insertion/Deletion) in -1171 5A > 6A in the MMP-3 promoter regions of patients with oral submucous fibrosis and in healthy individuals (controls).

Methods:

Thirty cases of OSF were categorized according to Khanna et al classification into four groups and Twenty age and sex matched controls were included in the study. Blood samples were collected in EDTA coated vacutainers and PCR restriction analysis was done. A statistical analysis was done using Chi-square test and Fisher's exact test to assess the frequency and association of the alleles in the case-control group.

Results:

The result showed a statistical significance difference between the duration of habit and disease severity with polymorphisms. The result also showed a higher frequency of the 5A allele in the study group as compared to the controls.

Conclusion:

A long-term follow up of these patients is mandatory to see the prognosis and their susceptibility to malignancy. The positive outcome of an association of the disease with polymorphisms would result in the development of potential diagnostic and therapeutic possibilities in potentially malignant and malignant lesions (AU)
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Oral Submucous Fibrosis / Oropharynx / Polymorphism, Genetic / Matrix Metalloproteinase 3 / Mouth Limits: Female / Humans / Male Language: English Journal: Appl. cancer res Journal subject: Neoplasms Year: 2017 Type: Article Affiliation country: India Institution/Affiliation country: College of Dental Sciences and Hospital-SDM/IN / College of Dental Sciences-SDM/IN / PC Jabin College/IN

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Full text: Available Index: LILACS (Americas) Main subject: Oral Submucous Fibrosis / Oropharynx / Polymorphism, Genetic / Matrix Metalloproteinase 3 / Mouth Limits: Female / Humans / Male Language: English Journal: Appl. cancer res Journal subject: Neoplasms Year: 2017 Type: Article Affiliation country: India Institution/Affiliation country: College of Dental Sciences and Hospital-SDM/IN / College of Dental Sciences-SDM/IN / PC Jabin College/IN