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Gastrointestinal stromal tumors treated at a Brazilian Cancer Center: evaluation of clinical, epidemiological, and therapeutic profiles
Landim, Erinaldo Rocha Paes; Jaqueta, Carolina de Barros; Chojniak, Rubens; Coimbra, Felipe José Fernandez; Mello, Celso Abdon Lopes de; Oriani, Patricia; Bitencourt, Almir Galvão Vieira; Paes, Luana de Paula Silva.
  • Landim, Erinaldo Rocha Paes; A.C.Camargo Cancer Center. Imaging Department. São Paulo. BR
  • Jaqueta, Carolina de Barros; A.C.Camargo Cancer Center. Imaging Department. São Paulo. BR
  • Chojniak, Rubens; A.C.Camargo Cancer Center. Imaging Department. São Paulo. BR
  • Coimbra, Felipe José Fernandez; A.C.Camargo Cancer Center. Department of Abdomen. São Paulo. BR
  • Mello, Celso Abdon Lopes de; A.C.Camargo Cancer Center. Department of Clinical Oncology. São Paulo. BR
  • Oriani, Patricia; A.C.Camargo Cancer Center. Imaging Department. São Paulo. BR
  • Bitencourt, Almir Galvão Vieira; A.C.Camargo Cancer Center. Imaging Department. São Paulo. BR
  • Paes, Luana de Paula Silva; A.C.Camargo Cancer Center. Nursing Department. São Paulo. BR
Appl. cancer res ; 37: 1-6, 2017. ilus
Article in English | LILACS, Inca | ID: biblio-911499
ABSTRACT

Background:

Gastrointestinal stromal tumors (GISTs) originate as precursor cells of the interstitial cells of Cajal in the myenteric plexus and generally have a mutation in the tyrosine kinase receptor, C-KIT (CD117). The objective is to evaluate the clinical, epidemiological, and therapeutic profiles of GIST cases available from a hospital specializing in cancer treatment.

Methods:

A retrospective, longitudinal study of 85 GIST cases in a Cancer Center (São Paulo, Brazil) was conducted.

Results:

The cases identified involved 40 men and 45 women and the average age at diagnosis was 55.7 ± 14. 8 years (median, 57). The symptoms present at diagnosis depended on the location and dimensions of each lesion. In 49 cases (57.6%), the tumors had a gastric location and the mean dimensions were 7.2 ± 2.3 cm (median, 3.4 cm). Recurrent metastatic disease presented in 27 cases (with the liver mainly affected). Locoregional recurrence was detected in 16 cases. C-KIT was positive in 79/81 (97.5%) of the cases examined. Most of the tumors were initially treated with surgery, while clinical treatment was applied to the recurrent cases. The overall survival rate was 76.4% 162 months after diagnosis.

Conclusions:

The GISTs examined most commonly originated in the stomach, while the liver was the main site affected by metastatic lesions. Most of the lesions appeared to be slow-growing neoplasms that were positive for C-KIT (CD117). Complications, as well as death, mostly affected the elderly patients that had comorbidities or more aggressive forms of the disease (AU)
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Stromal Cells / Receptor Protein-Tyrosine Kinases / Gastrointestinal Stromal Tumors Type of study: Observational study Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Appl. cancer res Journal subject: Neoplasms Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: A.C.Camargo Cancer Center/BR

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Full text: Available Index: LILACS (Americas) Main subject: Stromal Cells / Receptor Protein-Tyrosine Kinases / Gastrointestinal Stromal Tumors Type of study: Observational study Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Appl. cancer res Journal subject: Neoplasms Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: A.C.Camargo Cancer Center/BR