The genetic and epigenetic landscapes of hepatoblastomas
Appl. cancer res
;
37: 1-7, 2017. ilus
Article
in English
| LILACS, Inca
| ID: biblio-911514
ABSTRACT
Primary liver cancers are rare in children, and the most common type is hepatoblastoma (HB), an embryonal tumor with histological features that resemble different stages of liver cell differentiation. However, mainly because of its rarity, molecular data on HB tumorigenesis remain scarce. This article reviews the current knowledge regarding genetic and epigenetic alterations reported in HB cases, with emphasis on the recent findings of next-generation sequencing studies (AU)
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Child
/
Hepatoblastoma
/
Neoplasms, Germ Cell and Embryonal
/
Genetic Predisposition to Disease
/
Epigenomics
/
Liver Neoplasms
/
Mutation
Limits:
Humans
Language:
English
Journal:
Appl. cancer res
Journal subject:
Neoplasms
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
A.C.Camargo Cancer Center/BR
/
University of São Paulo/BR
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