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The genetic and epigenetic landscapes of hepatoblastomas
Aguiar, Talita Ferreira Marques; Carneiro, Thaise Nayane; Costa, Cecilia Maria Lima; Rosenberg, Carla; Cunha, Isabela Werneck; Krepischi, Ana Cristina Victorino.
  • Aguiar, Talita Ferreira Marques; A.C.Camargo Cancer Center. International Research Center. São Paulo. BR
  • Carneiro, Thaise Nayane; University of São Paulo. Institute of Biosciences. Department of Genetics and Evolutionary Biology. São Paulo. BR
  • Costa, Cecilia Maria Lima; A.C.Camargo Cancer Center. Department of Pediatric. São Paulo. BR
  • Rosenberg, Carla; University of São Paulo. Institute of Biosciences. Department of Genetics and Evolutionary Biology. São Paulo. BR
  • Cunha, Isabela Werneck; A.C.Camargo Cancer Center. Department of Pathology. São Paulo. BR
  • Krepischi, Ana Cristina Victorino; University of São Paulo. Institute of Biosciences. Department of Genetics and Evolutionary Biology. São Paulo. BR
Appl. cancer res ; 37: 1-7, 2017. ilus
Article in English | LILACS, Inca | ID: biblio-911514
ABSTRACT
Primary liver cancers are rare in children, and the most common type is hepatoblastoma (HB), an embryonal tumor with histological features that resemble different stages of liver cell differentiation. However, mainly because of its rarity, molecular data on HB tumorigenesis remain scarce. This article reviews the current knowledge regarding genetic and epigenetic alterations reported in HB cases, with emphasis on the recent findings of next-generation sequencing studies (AU)
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Full text: Available Index: LILACS (Americas) Main subject: Child / Hepatoblastoma / Neoplasms, Germ Cell and Embryonal / Genetic Predisposition to Disease / Epigenomics / Liver Neoplasms / Mutation Limits: Humans Language: English Journal: Appl. cancer res Journal subject: Neoplasms Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: A.C.Camargo Cancer Center/BR / University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Child / Hepatoblastoma / Neoplasms, Germ Cell and Embryonal / Genetic Predisposition to Disease / Epigenomics / Liver Neoplasms / Mutation Limits: Humans Language: English Journal: Appl. cancer res Journal subject: Neoplasms Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: A.C.Camargo Cancer Center/BR / University of São Paulo/BR