Association between the IL28B rs12979860 POLYMORPHISM and therapy response in patients infected with genotype 1 of hepatitis c virus in central Brazil
Rev. patol. trop
;
45(2): 152-160, jun. 2016. tab
Article
in English
| LILACS
| ID: biblio-913207
ABSTRACT
Single nucleotide polymorphisms (SNPs) upstream of the IL28B gene have been associated with the spontaneous clearance of hepatitis C virus (HCV) and with a sustained virological response (SVR) to HCV infection treatment. This study aimed to investigate the association between IL28B SNP rs12979860 and SVR in patients with hepatitis C in Central Brazil. A total of 101 HCV genotype 1 mono-infected chronic patients treated with pegylated interferon and ribavirin (PEG-IFN/RBV) were studied in the City of Goiânia, Central Brazil. Analysis of rs12979860 showed that the most prevalent genotype was CT (57.4%), followed by CC (23.8%) and TT (18.8%). An overall SVR rate of 28.7% (95% CI 20.4-38.7) was found in the study population. In a multivariate analysis, only IL28B rs12979860 CC genotype (OR 3.77; 95% CI 1.13-12.60; p = 0.031) was associated with SVR. These findings show that IL28B SNP rs12979860 is a strong predictor of SVR in the PEG-IFN/RBV treatment in patients infected with genotype 1 of HCV in Central Brazil
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Hepatitis C
Type of study:
Prognostic study
/
Risk factors
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. patol. trop
Journal subject:
Tropical Medicine
/
Pathology
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade de Enfermagem/BR
/
Faculdade de Medicina, UFG/BR
/
Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás (UFG)/BR
Similar
MEDLINE
...
LILACS
LIS