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Profile of exoantigens from clinical isolates of Paracoccidioides lutzii IN Mato Grosso, Brazil
Grossklaus, Daciene de Arruda; Takahara, Doracilde Terumi; Kruger, Cleoni Silvana; Gonzaga, Andrea Maria; Camargo, Zoilo Pires de; Nery, Andreia Ferreira; Almeida, Hugo Luciano; Hahn, Rosane Christine.
  • Grossklaus, Daciene de Arruda; Post-Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Mato Grosso. Cuiabá. BR
  • Takahara, Doracilde Terumi; Post-Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Mato Grosso. Department of Epidemiological Surveillance Coordination, Central Laboratory (LACEN-MT). Cuiabá. BR
  • Kruger, Cleoni Silvana; Assistant Secretary of Policy and Health Care Department of Health, State Department of Health, SES. Cuiabá. BR
  • Gonzaga, Andrea Maria; Department of Epidemiological Surveillance Coordination, Central Laboratory (LACEN-MT). Cuiabá. BR
  • Camargo, Zoilo Pires de; Mycology Laboratory, Federal University of São Paulo (UNIFESP). São Paulo. BR
  • Nery, Andreia Ferreira; Post-Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Mato Grosso. Cuiabá. BR
  • Almeida, Hugo Luciano; Post-Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Mato Grosso. Cuiabá. BR
  • Hahn, Rosane Christine; Department of Epidemiological Surveillance Coordination, Central Laboratory (LACEN-MT). Laboratory Research / Mycology, Faculty of Medicine, Federal University of Mato Grosso,. Cuiabá. BR
Rev. patol. trop ; 45(3): 265-272, set. 2016. tab, ilus
Article in English | LILACS | ID: biblio-913231
Responsible library: BR816.9
ABSTRACT
The objective of this study was to determine the immunochemical profile of three exoantigen preparations obtained from clinical samples of Paracoccidioides lutzii from the state of Mato Grosso, Brazil. The exoantigens were prepared according to a protocol standardized by Camargo et al. and their immunochemical profiles were analyzed using SDS-PAGE. The observed protein bands exhibited molecular weights of 20, 30, and 130 kDa. The 130 kDa glycoprotein was detected in all three preparations. The detection of this high-molecular-weight protein suggests a distinct immunochemical profile. These differences may help to explain the false negative reactions obtained when using the antigen from P. brasiliensis reference strain B-339. This information is essential for increasing the specificity of serological tests used to monitor the prognosis of patients with paracoccidioidomycosis.
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Full text: Available Index: LILACS (Americas) Main subject: Paracoccidioides Country/Region as subject: South America / Brazil Language: English Journal: Rev. patol. trop Journal subject: Tropical Medicine / Pathology Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Assistant Secretary of Policy and Health Care Department of Health, State Department of Health, SES/BR / Department of Epidemiological Surveillance Coordination, Central Laboratory (LACEN-MT)/BR / Mycology Laboratory, Federal University of São Paulo (UNIFESP)/BR / Post-Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Mato Grosso/BR

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Full text: Available Index: LILACS (Americas) Main subject: Paracoccidioides Country/Region as subject: South America / Brazil Language: English Journal: Rev. patol. trop Journal subject: Tropical Medicine / Pathology Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Assistant Secretary of Policy and Health Care Department of Health, State Department of Health, SES/BR / Department of Epidemiological Surveillance Coordination, Central Laboratory (LACEN-MT)/BR / Mycology Laboratory, Federal University of São Paulo (UNIFESP)/BR / Post-Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Mato Grosso/BR