Usefulness of an elisa kit for the detection of Histoplasma capsulatum antigen in patients with AIDS
Rev. patol. trop
;
46(2): 135-145, jun. 2017. tab
Article
in English
| LILACS
| ID: biblio-913455
ABSTRACT
Histoplasmosis is a systemic mycosis frequently affecting patients infected with HIV, appearing as acute or subacute disseminated forms. Early diagnosis is simple when muco-cutaneous lesions are present; but in their absence the use of non-culture based methods is usually required presenting a fundamental challenge for the management and prognosis of this infection. The aim of this study was to analyze the sensitivity and specificity of an Elisa kit for the detection of the galactomannan antigen of Histoplasma capsulatum in different clinical samples. A total of 98 clinical samples obtained from different organic fluids were analyzed 66 sera, 28 urine samples, 3 bronchoalveolar lavages and one cerebrospinal fluid. They corresponded to a total of 61 patients 27 with histoplasmosis associated with AIDS, 7 histoplasmosis in nonreactive HIV individuals and 27 patients with other diseases but which were clinically similar to histoplasmosis. The sensitivity of the detection of the galactomannan antigen in serum of patients with histoplasmosis and AIDS was 76% and the specificity was 56%. In urine samples of this group of patients the sensitivity was 75%
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Index:
LILACS (Americas)
Main subject:
Histoplasmosis
Type of study:
Diagnostic study
/
Screening study
Language:
English
Journal:
Rev. patol. trop
Journal subject:
Tropical Medicine
/
Pathology
Year:
2017
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Mycology Unit of the Infectious Diseases Hospital FJ Muñiz/AR
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