Sepsis-induced acute kidney injury: biomarkers for diagnosis
Rev. patol. trop
;
46(3): 221-232, set. 2017.
Article
in English
| LILACS
| ID: biblio-913684
ABSTRACT
Sepsis is a major global health problem leading to the increased incidence of death in intensive care units. In recent years, despite technological advances, the number of cases has grown significantly. Among the main complications presented by septic patients, acute renal dysfunction is largely responsible for the high mortality rate. Initially, the reduction of renal function is associated with focal tubular injury with preserved glomerular morphology and systemic hemodynamic alterations. During sepsis development, the progressive decrease in urinary volume and reduction of the glomerular filtration rate associated with increased serum levels of urea and creatinine are considered classic markers of severe kidney injury. Despite the valuable role of these serum markers regarding renal function, these data provide an incomplete scenario of the patient, since many renal disorders may occur in individuals with increased plasma concentrations of urea and creatinine. Taking into account the important role of systemic inflammatory processes in the development of acute kidney injury induced by sepsis, the search for new markers presenting high sensitivity and specificity capable of detecting early renal injury is still necessary. Thus, the present review summarizes important aspects of pathophysiology of acute kidney dysfunction induced by sepsis and presents an updated view of possible new biomarkers associated with the development of acute kidney injury. Understanding these markers allows important advances leading to new therapeutic approaches, indicating a new horizon in the diagnosis and treatment of acute kidney injury in sepsis
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Sepsis
Type of study:
Diagnostic study
Language:
English
Journal:
Rev. patol. trop
Journal subject:
Tropical Medicine
/
Pathology
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Department of Histology, Embryology and Cellular Biology, University of Rio Verde/BR
/
Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo/BR
/
Department of Pathology, Institute of Tropical Pathology and Public Health (IPTSP), Federal University of Goias (UFG)/BR
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