SIVA, a target of p53, is downregulated in myelodysplastic syndromes
Appl. cancer res
;
37: 1-7, 2017. tab, ilus
Article
in English
| LILACS, Inca
| ID: biblio-915402
ABSTRACT
Background:
SIVA is a transcriptional target of p53 that plays a potential role in the development and progression of cancer. In this study, we analyzed SIVA1 and SIVA2 expression, and its association with clinical features and TP53 and MDM2 expression in bone marrow cells from healthy donors and myelodysplastic syndrome (MDS) patients.Methods:
Fifty-five untreated patients with MDS and 22 healthy donors were included. Gene expression was evaluated by quantitative PCR. For statistical analysis, MannWhitney test, Spearman correlation analysis and Log-rank (Mantel-Cox) were used, as appropriate. A p value <0.05 was considered statistically significant.Results:
SIVA1 and SIVA2 transcripts were significantly decreased in bone marrow samples from MDS patients compared to healthy donors, and positively correlated with MDM2 and TP53 expression in MDS patients (all p < 0.05). MDM2 expression was also downregulated in bone marrow samples from MDS patients compared to healthy donors (p < 0.05). However, SIVA1, SIVA2, MDM2 and TP53 expressions did not impact on MDS outcomes.Conclusions:
SIVA1 and SIVA2 transcripts are downregulated in bone marrow samples from MDS patients (AU)
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Myelodysplastic Syndromes
/
Genes, p53
/
Apoptosis Inducing Factor
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Appl. cancer res
Journal subject:
Neoplasms
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
University of Campinas, Hemocentro-Unicamp/BR
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