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Maternal risk factors for the transmission of congenital chagas disease
Suasnábar, Santiago Martín; Olivera, Lorena Verónica; Bizai, Maria Laura; Arias, Evelyn Elizabeth; Denner, Susana; Fabbro, Diana Lucrecia.
  • Suasnábar, Santiago Martín; Centro de Investigaciones sobre Endemias Nacionales (CIEN), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral. Santa Fé. AR
  • Olivera, Lorena Verónica; Centro de Investigaciones sobre Endemias Nacionales (CIEN), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral. Santa Fé. AR
  • Bizai, Maria Laura; Centro de Investigaciones sobre Endemias Nacionales (CIEN), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral. Santa Fé. AR
  • Arias, Evelyn Elizabeth; Centro de Investigaciones sobre Endemias Nacionales (CIEN), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral. Santa Fé. AR
  • Denner, Susana; Centro de Investigaciones sobre Endemias Nacionales (CIEN), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral. Santa Fé. AR
  • Fabbro, Diana Lucrecia; Centro de Investigaciones sobre Endemias Nacionales (CIEN), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral. Santa Fé. AR
Rev. patol. trop ; 47(3): 133-144, set. 2018. tab, ilus
Article in English | LILACS | ID: biblio-946895
ABSTRACT
The present article looks at the association between the epidemiological history of women infected with Trypanosoma cruzi and the risk of vertical transmission. Eighty-three chronically infected mothers and their 237 children were studied, using a cohort design. All patients reside in Santa Fe city, Argentina. Twenty-five women transmitted the infection to 38 children. The potential risk factors evaluated in the mothers were exposure to vector transmission, blood transfusion history, maternal seropositivity, parasitemia and age at birth of the child. 72% (18/25) of the mothers who transmitted the infection to their children, had little or no contact with the vector, while only 28% (7/25) of the mothers presented a history of medium or high risk of vector infection. The differences were significant (p < 0.05). Forty-one percent of the women who presented maternal history as the probable route of infection, transmitted the parasite to more than one child (1.86 ± 0.33; CI95% = 1.03-2.68). In addition, the most frequent history, among the women who transmitted the disease to their children, was the absence of exposure to vector transmission and transfusion with unknown maternal serology. The route of infection was probably transplacental. These observations suggest that there are family genetic characteristics involved in vertical transmission. The parasite was found in 71% of the mothers who transmitted the infection to their children and were able to perform xenodiagnoses. After controlling for the other variables, the logistic regression analysis showed that xenodiagnosis (+) is a risk factor for congenital transmission; the relative risk was 12.2 (95% confidence interval 2.9 - 50.1). No differences were found when analyzing the mother's age and transfusion history. The highest risk of congenital transmission was associated with detectable parasitemia and less maternal exposure to the vector.
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Full text: Available Index: LILACS (Americas) Main subject: Risk Factors / Chagas Disease Type of study: Etiology study / Risk factors Limits: Child / Female / Humans / Pregnancy Language: English Journal: Rev. patol. trop Journal subject: Tropical Medicine / Pathology Year: 2018 Type: Article Affiliation country: Argentina Institution/Affiliation country: Centro de Investigaciones sobre Endemias Nacionales (CIEN), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral/AR

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Full text: Available Index: LILACS (Americas) Main subject: Risk Factors / Chagas Disease Type of study: Etiology study / Risk factors Limits: Child / Female / Humans / Pregnancy Language: English Journal: Rev. patol. trop Journal subject: Tropical Medicine / Pathology Year: 2018 Type: Article Affiliation country: Argentina Institution/Affiliation country: Centro de Investigaciones sobre Endemias Nacionales (CIEN), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral/AR