Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies
Acta cir. bras
;
33(5): 446-453, May 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-949343
ABSTRACT
Abstract Purpose:
To evaluate the response of aging rats with sepsis to two different antibiotic regimens.Methods:
The study was conducted with 30 aging rats (18 month-old) with autologous feces peritonitis. The animals were divided into three groups Group 0 received no therapeutic intervention (control), while Group 1 received a single dose of 40 mg/kg meropenem and Group 2 received a single dose of 20 mg/kg moxifloxacin. The intervention in both Groups was made 6 hours after induction of peritonitis. The animals were followed up to 15 days for evaluating morbidity and mortality. The weights at baseline were similar in all groups.Results:
At the end of follow-up, weight loss was significantly greater (p=0.0045) in Group 0 (non-intervention controls). Culture from a blood sample at the end of follow-up was positive in all the animals in Group 0, in two animals in Group 1 and in four animals in Group 2. Morbidity/mortality was significantly higher in Group 0 compared to both Groups 1 and 2 (p=0.003) but the scores were not significantly different between Groups 1 and 2 (p=0.6967).Conclusion:
Both antibiotic regimens rendered promising results for the treatment of fecal peritonitis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Peritonitis
/
Bacteroides Infections
/
Aging
/
Anti-Bacterial Agents
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
UFPE/BR
/
UNIFACISA/BR
/
Universidade Federal de Campina Grande/BR
/
Universidade Federal de Pernambuco/BR
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