Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model
Acta cir. bras
;
33(5): 420-430, May 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-949349
ABSTRACT
Abstract Purpose:
To evaluate the effects of red propolis on cheek pouch angiogenesis in a hamster new model sponge implant.Methods:
Forty eight animals divided into eight groups. (Groups I-IV), the animals were treated for 15 days before and 10 days after sponge implantation. (Groups V-VIII), the animals were treated for 10 days after sponge implantation (GI and GV red propolis 100 mg/kg, GII and GVI celecoxib 20 mg/kg, GIII and GVII 1% gum arabic 5 mL/kg, GIV and GVIII distilled water 5 mL/kg). On the 11th day of implantation, the animals were anesthetized for stereoscopic microscopic imaging and morphometric quantification of angiogenesis (SQAN), followed by histopathological evaluation (H&E).Results:
In the SQAN analysis, no significant difference was found between the groups. However, on histology, propolis was found reduce the population of mastocytes in the qualitative analyses (p = 0,013) in the quantitative analyses to reduce the number of blood vessels (p = 0,007), and increase the macrophage count (p = 0,001).Conclusion:
Red propolis inhibited inflammatory angiogenesis when administered before andcontinuously after sponge implant, and was shown to have immunomodulating effects on inflammatory cells (mastocytes and macrophages) in a new sponge implant hamster model.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Propolis
/
Prostheses and Implants
/
Surgical Sponges
/
Inflammation
/
Neovascularization, Pathologic
Type of study:
Qualitative research
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
UFC/BR
/
Universidade Federal do Ceará/BR
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