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Impact of 1 25(OH) 2 D 3 on TG content in liver of rats with type 2 diabetes
Yang, Yan; Liu, Beibei; Gao, Ling; Li, Qi; Wang, He; Wang, Liandi.
  • Yang, Yan; Affiliated Hospital of Zunyi Medical College. Department of Endocrinology. CN
  • Liu, Beibei; Affiliated Hospital of Zunyi Medical College. Department of Endocrinology. CN
  • Gao, Ling; Affiliated Hospital of Zunyi Medical College. Department of Endocrinology. CN
  • Li, Qi; Affiliated Hospital of Zunyi Medical College. Department of Endocrinology. CN
  • Wang, He; Affiliated Hospital of Zunyi Medical College. Department of Endocrinology. CN
  • Wang, Liandi; Affiliated Hospital of Zunyi Medical College. Department of Endocrinology. CN
Acta cir. bras ; 33(6): 542-550, June 2018. tab, graf
Article in English | LILACS | ID: biblio-949355
ABSTRACT
Abstract

Purpose:

To evaluate the effects of 1,25 dihydroxy vitamin D3 (1,25(OH)2D3) on the content of triglyceride (TG), as well as on the gene and protein expressions of adiponectin receptor 2 (AdipoR2), p38 mitogen-activated protein kinase (P38MAPK), and lipoprotein lipase (LPL) in the liver of rats with type 2 diabetes mellitus (T2DM) so as to provide theoretical basis for exploring the mechanism by which 1,25(OH)2D3 regulates TG.

Methods:

Wistar rats were divided into four groups (n=25), with different treatments and detected the gene and protein expressions of AdipoR2, p38MAPK, and LPL in the liver tissue by reverse transcription polymerase chain reaction (RT-PCR) and Western blotting. Meanwhile, the content of TG in the liver tissue was detected by the Enzyme-linked immunosorbent assay.

Results:

The expression of AdipoR2, p38MAPK, LPL gene and protein in the liver of VitD intervention group was significantly higher than that in T2DM group (P <0.05), while the TG content was significantly lower than that in T2DM group (P <0.05).

Conclusion:

1,25(OH)2D3 can decrease the content of TG in the liver, and its mechanism may be achieved by upregulating the expressions of AdipoR2, p38MAPK, and LPL in the liver.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Triglycerides / Calcitriol / Diabetes Mellitus, Type 2 / Liver Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Affiliated Hospital of Zunyi Medical College/CN

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Full text: Available Index: LILACS (Americas) Main subject: Triglycerides / Calcitriol / Diabetes Mellitus, Type 2 / Liver Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Affiliated Hospital of Zunyi Medical College/CN