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Antioxidant extract counteracts the effects of aging on cortical spreading depression and oxidative stress in the brain cortex
Sousa, Mariana Séfora Bezerra; Holanda, Iasmym Melissa Soares de; Monteiro, Heloísa Mirelle Costa; Amâncio-dos-Santos, Ângela.
  • Sousa, Mariana Séfora Bezerra; Universidade Federal de Pernambuco. Center for Health Sciences. Department of Nutrition. Recife. BR
  • Holanda, Iasmym Melissa Soares de; UFPE. Biosciences Center. Department of Physiology and Pharmacology. Recife. BR
  • Monteiro, Heloísa Mirelle Costa; Universidade Federal de Pernambuco. Center for Health Sciences. Department of Nutrition. Recife. BR
  • Amâncio-dos-Santos, Ângela; UFPE. Biosciences Center. Department of Physiology and Pharmacology. Recife. BR
Acta cir. bras ; 33(6): 472-482, June 2018. tab, graf
Article in English | LILACS | ID: biblio-949356
Responsible library: BR1.1
ABSTRACT
Abstract

Purpose:

To investigate the effects of Murici extract on the brain excitability-dependent phenomenon known as cortical spreading depression (CSD) and on brain oxidative stress.

Methods:

Adult and aged Wistar rats were supplemented with murici extract (150 mg/kg/day or 300 mg/kg/day) by gavage for fifteen days. Afterwards, the animals were submitted to a CSD electrophysiological recording and to brain oxidative stress evaluation.

Results:

Our results showed that aging decreased CSD propagation velocity, catalase activity and glutathione/oxidized glutathione ratio (GSH/GSSG) in the brain cortex of the rats, and increased malondialdehyde (MDA) concentrations and superoxide dismutase (SOD) activity. The highest dose (300 mg/kg/day) of murici extract accelerated CSD, whereas the lowest (150mg/kg/day) decelerated, in both adult and aged animals. In contrast, aged animals supplemented with murici extract in both doses presented low MDA levels and high GSG/GSSG ratio in comparison to the control-aged animals.

Conclusion:

Murici extract supplementation seems to revert detrimental effects in aged brains and could be considered as a strategy in the treatment of pathologies related to aging and cortical spreading depression.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Aging / Cerebral Cortex / Oxidative Stress / Malpighiaceae / Antioxidants Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: UFPE/BR / Universidade Federal de Pernambuco/BR

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Full text: Available Index: LILACS (Americas) Main subject: Aging / Cerebral Cortex / Oxidative Stress / Malpighiaceae / Antioxidants Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: UFPE/BR / Universidade Federal de Pernambuco/BR