Antioxidant extract counteracts the effects of aging on cortical spreading depression and oxidative stress in the brain cortex
Acta cir. bras
;
33(6): 472-482, June 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-949356
ABSTRACT
Abstract Purpose:
To investigate the effects of Murici extract on the brain excitability-dependent phenomenon known as cortical spreading depression (CSD) and on brain oxidative stress.Methods:
Adult and aged Wistar rats were supplemented with murici extract (150 mg/kg/day or 300 mg/kg/day) by gavage for fifteen days. Afterwards, the animals were submitted to a CSD electrophysiological recording and to brain oxidative stress evaluation.Results:
Our results showed that aging decreased CSD propagation velocity, catalase activity and glutathione/oxidized glutathione ratio (GSH/GSSG) in the brain cortex of the rats, and increased malondialdehyde (MDA) concentrations and superoxide dismutase (SOD) activity. The highest dose (300 mg/kg/day) of murici extract accelerated CSD, whereas the lowest (150mg/kg/day) decelerated, in both adult and aged animals. In contrast, aged animals supplemented with murici extract in both doses presented low MDA levels and high GSG/GSSG ratio in comparison to the control-aged animals.Conclusion:
Murici extract supplementation seems to revert detrimental effects in aged brains and could be considered as a strategy in the treatment of pathologies related to aging and cortical spreading depression.
Full text:
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Index:
LILACS (Americas)
Main subject:
Aging
/
Cerebral Cortex
/
Oxidative Stress
/
Malpighiaceae
/
Antioxidants
Type of study:
Evaluation studies
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
UFPE/BR
/
Universidade Federal de Pernambuco/BR
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